Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3663246..3663951 Replicon chromosome
Accession NZ_CP120944
Organism Escherichia coli O157:H7 str. EDL933

Toxin (Protein)


Gene name relE Uniprot ID Q8X3N0
Locus tag P7249_RS18850 Protein ID WP_000539519.1
Coordinates 3663246..3663632 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag P7249_RS18855 Protein ID WP_001280945.1
Coordinates 3663622..3663951 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7249_RS18830 (3659250) 3659250..3659876 + 627 WP_001295292.1 glutathione S-transferase GstB -
P7249_RS18835 (3659873) 3659873..3660988 - 1116 WP_000554959.1 aldose sugar dehydrogenase YliI -
P7249_RS18840 (3661099) 3661099..3661482 - 384 WP_000497137.1 biofilm formation regulator BssR -
P7249_RS18845 (3661695) 3661695..3663020 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
P7249_RS18850 (3663246) 3663246..3663632 + 387 WP_000539519.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P7249_RS18855 (3663622) 3663622..3663951 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
P7249_RS18860 (3664021) 3664021..3665349 - 1329 WP_000086905.1 GGDEF domain-containing protein -
P7249_RS18865 (3665357) 3665357..3667705 - 2349 WP_000950320.1 EAL domain-containing protein -
P7249_RS18870 (3667883) 3667883..3668794 - 912 WP_001236044.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14279.42 Da        Isoelectric Point: 9.9296

>T275457 WP_000539519.1 NZ_CP120944:3663246-3663632 [Escherichia coli O157:H7 str. EDL933]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGSKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT275457 WP_001280945.1 NZ_CP120944:3663622-3663951 [Escherichia coli O157:H7 str. EDL933]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References