275455

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2676886..2677524 Replicon chromosome
Accession NZ_CP120944
Organism Escherichia coli O157:H7 str. EDL933

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag P7249_RS13500 Protein ID WP_000813794.1
Coordinates 2676886..2677062 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag P7249_RS13505 Protein ID WP_001270286.1
Coordinates 2677108..2677524 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7249_RS13480 (2672508) 2672508..2673680 - 1173 WP_001236316.1 BenE family transporter YdcO -
P7249_RS13485 (2673772) 2673772..2674308 + 537 WP_000429145.1 DNA-binding transcriptional regulator SutR -
P7249_RS13490 (2674381) 2674381..2676342 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
P7249_RS13495 (2676434) 2676434..2676664 - 231 WP_000494244.1 YncJ family protein -
P7249_RS13500 (2676886) 2676886..2677062 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
P7249_RS13505 (2677108) 2677108..2677524 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
P7249_RS13510 (2677603) 2677603..2679009 + 1407 WP_000760654.1 PLP-dependent aminotransferase family protein -
P7249_RS13515 (2679254) 2679254..2680399 + 1146 WP_000047432.1 ABC transporter substrate-binding protein -
P7249_RS13520 (2680417) 2680417..2681430 + 1014 WP_000220402.1 ABC transporter ATP-binding protein -
P7249_RS13525 (2681431) 2681431..2682372 + 942 WP_001251320.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T275455 WP_000813794.1 NZ_CP120944:2676886-2677062 [Escherichia coli O157:H7 str. EDL933]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT275455 WP_001270286.1 NZ_CP120944:2677108-2677524 [Escherichia coli O157:H7 str. EDL933]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References