275442

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 401241..401995 Replicon chromosome
Accession NZ_CP120944
Organism Escherichia coli O157:H7 str. EDL933

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag P7249_RS01920 Protein ID WP_001301452.1
Coordinates 401241..401726 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID Q8X700
Locus tag P7249_RS01925 Protein ID WP_000801912.1
Coordinates 401717..401995 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7249_RS01900 (396407) 396407..397165 + 759 WP_001302007.1 DeoR/GlpR family transcriptional regulator -
P7249_RS01905 (397147) 397147..398745 - 1599 WP_001232889.1 DNA-binding transcriptional regulator RtcR -
P7249_RS01910 (398933) 398933..400159 + 1227 WP_001105473.1 RNA-splicing ligase RtcB -
P7249_RS01915 (400163) 400163..401191 + 1029 WP_000827117.1 RNA 3'-terminal phosphate cyclase -
P7249_RS01920 (401241) 401241..401726 - 486 WP_001301452.1 GNAT family N-acetyltransferase Toxin
P7249_RS01925 (401717) 401717..401995 - 279 WP_000801912.1 DUF1778 domain-containing protein Antitoxin
P7249_RS01930 (402062) 402062..404767 - 2706 WP_000906970.1 HTH-type transcriptional regulator MalT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-143)

Antitoxin

Vibrio phage ICP1, Orf50

(2-92)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17650.57 Da        Isoelectric Point: 9.4066

>T275442 WP_001301452.1 NZ_CP120944:c401726-401241 [Escherichia coli O157:H7 str. EDL933]
MGITAPTPLTSEHNLADFCCSDHGMNEWLKKKALKNHSSGLSRVYVICIANTRQVIGYYCLSTGSIQRNLAPGAMRRNAP
ESLPVVVLGRLAIDQAWAGKGLGVALLKDAVYRTMSIAQQVGVRALIVHALDDSVRNFYLKYAFVPSPFQSLTLLYPITL
E

Download         Length: 486 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10420.94 Da        Isoelectric Point: 4.6336

>AT275442 WP_000801912.1 NZ_CP120944:c401995-401717 [Escherichia coli O157:H7 str. EDL933]
MKPESKEAPINIRAKASQRDLIDMAANLVAKSRTDFMLDAACREAQDILLDQRLFILDDEQYDAFLAALDAPITAERQAK
INALMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LHB9

References