Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4439920..4441493 Replicon chromosome
Accession NZ_CP120942
Organism Aeromonas caviae strain AC1520

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag P5S46_RS20785 Protein ID WP_042864682.1
Coordinates 4439920..4441239 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag P5S46_RS20790 Protein ID WP_017410478.1
Coordinates 4441239..4441493 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5S46_RS20770 (P5S46_20770) 4435821..4436585 + 765 WP_277856455.1 ATP-binding cassette domain-containing protein -
P5S46_RS20775 (P5S46_20775) 4436617..4437519 + 903 WP_277857140.1 ABC transporter substrate-binding protein -
P5S46_RS20780 (P5S46_20780) 4437516..4439498 + 1983 WP_277856456.1 Fe(3+)-hydroxamate ABC transporter permease FhuB -
P5S46_RS20785 (P5S46_20785) 4439920..4441239 - 1320 WP_042864682.1 type II toxin-antitoxin system HipA family toxin Toxin
P5S46_RS20790 (P5S46_20790) 4441239..4441493 - 255 WP_017410478.1 helix-turn-helix domain-containing protein Antitoxin
P5S46_RS20795 (P5S46_20795) 4442019..4442594 - 576 WP_001173919.1 recombinase family protein -
P5S46_RS20800 (P5S46_20800) 4442721..4442969 - 249 WP_012585400.1 type II toxin-antitoxin system YafQ family toxin -
P5S46_RS20805 (P5S46_20805) 4443229..4444242 - 1014 WP_000845048.1 class 1 integron integrase IntI1 -
P5S46_RS20810 (P5S46_20810) 4444388..4444921 + 534 WP_000381802.1 aminoglycoside nucleotidyltransferase ANT(2'')-Ia -
P5S46_RS20815 (P5S46_20815) 4445151..4445951 + 801 WP_000846390.1 oxacillin-hydrolyzing class D beta-lactamase OXA-10 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island ant(2'')-Ia / blaOXA-10 / aadA2 / aph(3'')-Ib / aph(6)-Id / sul1 / tet(A) - 4439920..4476623 36703
- flank IS/Tn ant(2'')-Ia / blaOXA-10 / aadA2 / aph(3'')-Ib / aph(6)-Id / sul1 - 4442019..4453458 11439


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49588.58 Da        Isoelectric Point: 6.8291

>T275439 WP_042864682.1 NZ_CP120942:c4441239-4439920 [Aeromonas caviae]
MANLAVYMNGYRVGTFTKTTSGAHQFQYHESWLAQPGSRPISLSMPLRHQAYRGDEAYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYIDGRWYLPLKATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYESHGGPGITDIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASSKGKKYSIEQIFPRHFFQTAKTVGFERSAMEEILTELANSV
DDVIERVTQQLPADFPDTISSTILEGLKARSARLIKGWD

Download         Length: 1320 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9293.62 Da        Isoelectric Point: 7.9834

>AT275439 WP_017410478.1 NZ_CP120942:c4441493-4441239 [Aeromonas caviae]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSVDIKPRNESSESPASGW
KEEW

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References