Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 1744104..1745125 Replicon chromosome
Accession NZ_CP120942
Organism Aeromonas caviae strain AC1520

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag P5S46_RS08185 Protein ID WP_277856919.1
Coordinates 1744104..1744673 (-) Length 190 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag P5S46_RS08190 Protein ID WP_277856920.1
Coordinates 1744673..1745125 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5S46_RS08145 (P5S46_08145) 1739301..1739582 + 282 WP_277856913.1 hypothetical protein -
P5S46_RS08150 (P5S46_08150) 1739695..1740369 + 675 WP_236758823.1 phage regulatory protein/antirepressor Ant -
P5S46_RS08155 (P5S46_08155) 1740366..1740563 + 198 WP_005324004.1 DUF3283 family protein -
P5S46_RS08160 (P5S46_08160) 1740560..1741552 + 993 WP_277856914.1 DUF968 domain-containing protein -
P5S46_RS08165 (P5S46_08165) 1741539..1741925 + 387 WP_277856915.1 RusA family crossover junction endodeoxyribonuclease -
P5S46_RS08170 (P5S46_08170) 1742020..1742544 + 525 WP_277856916.1 antitermination protein -
P5S46_RS08175 (P5S46_08175) 1743215..1743466 + 252 WP_277856917.1 hypothetical protein -
P5S46_RS08180 (P5S46_08180) 1743485..1743829 + 345 WP_277856918.1 hypothetical protein -
P5S46_RS08185 (P5S46_08185) 1744104..1744673 - 570 WP_277856919.1 PIN domain-containing protein Toxin
P5S46_RS08190 (P5S46_08190) 1744673..1745125 - 453 WP_277856920.1 helix-turn-helix domain-containing protein Antitoxin
P5S46_RS08195 (P5S46_08195) 1745380..1745586 + 207 WP_045525020.1 hypothetical protein -
P5S46_RS08200 (P5S46_08200) 1745598..1746080 + 483 WP_277857110.1 lysozyme -
P5S46_RS08205 (P5S46_08205) 1746080..1746619 + 540 WP_277856921.1 DUF2514 family protein -
P5S46_RS08210 (P5S46_08210) 1746797..1747276 + 480 WP_045525024.1 terminase small subunit -
P5S46_RS08215 (P5S46_08215) 1747347..1749197 + 1851 WP_277856922.1 phage terminase large subunit family protein -
P5S46_RS08220 (P5S46_08220) 1749194..1749403 + 210 WP_277856923.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1687607..1868384 180777


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-113)

Antitoxin

Helix-turn-helix domain, group 17

(80-127)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 21217.30 Da        Isoelectric Point: 5.5716

>T275437 WP_277856919.1 NZ_CP120942:c1744673-1744104 [Aeromonas caviae]
MSSYVVLLDACVLYPAPLRSYLMYLAASGLYRARWTNQIHEEWISNLLSNRPDLTRPQLERTRNLMNHHAPDCLIVGYEP
LIDSLDLPDVDDRHVLAAAIRGQAEAIITFNLKDFPNGTLSGYGISAIHPDEFLSDMLALSPGECVKAAASQRAALRNPT
MNADEYLLSLQRQGLPRFVSDMQSYRLII

Download         Length: 570 bp

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16437.88 Da        Isoelectric Point: 5.2331

>AT275437 WP_277856920.1 NZ_CP120942:c1745125-1744673 [Aeromonas caviae]
MNTLSHMPSAAEVALAKLSSQELAACLEINGEGQELTIHDRSGNERTVKVPASALNLLVEVLTQLGQGNIVKITPIHAEL
TTQQAADMLNMSRPTMIKILDEGQIPYTRVGNRRKVAYAEIAKYKEELYANRLNTLAELAALDQEMGMGY

Download         Length: 453 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References