Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 570988..571624 Replicon chromosome
Accession NZ_CP120920
Organism Bacillus paralicheniformis strain SYN-191

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag P3X35_RS02855 Protein ID WP_003179128.1
Coordinates 571274..571624 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M5PDU2
Locus tag P3X35_RS02850 Protein ID WP_006638778.1
Coordinates 570988..571269 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P3X35_RS02830 (P3X35_02830) 566099..567583 + 1485 WP_277868558.1 PH domain-containing protein -
P3X35_RS02835 (P3X35_02835) 567580..568179 - 600 WP_277868559.1 rhomboid family intramembrane serine protease -
P3X35_RS02840 (P3X35_02840) 568523..569482 + 960 WP_165973180.1 outer membrane lipoprotein carrier protein LolA -
P3X35_RS02845 (P3X35_02845) 569707..570876 + 1170 WP_205689354.1 alanine racemase -
P3X35_RS02850 (P3X35_02850) 570988..571269 + 282 WP_006638778.1 hypothetical protein Antitoxin
P3X35_RS02855 (P3X35_02855) 571274..571624 + 351 WP_003179128.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
P3X35_RS02860 (P3X35_02860) 571742..572569 + 828 WP_023857863.1 RsbT co-antagonist protein RsbRA -
P3X35_RS02865 (P3X35_02865) 572573..572938 + 366 WP_031305225.1 STAS domain-containing protein -
P3X35_RS02870 (P3X35_02870) 572941..573342 + 402 WP_023857861.1 anti-sigma regulatory factor -
P3X35_RS02875 (P3X35_02875) 573353..574360 + 1008 WP_020450261.1 PP2C family protein-serine/threonine phosphatase -
P3X35_RS02880 (P3X35_02880) 574419..574745 + 327 WP_020450262.1 anti-sigma factor antagonist -
P3X35_RS02885 (P3X35_02885) 574745..575227 + 483 WP_020450263.1 anti-sigma B factor RsbW -
P3X35_RS02890 (P3X35_02890) 575193..575984 + 792 WP_023857858.1 RNA polymerase sigma factor SigB -
P3X35_RS02895 (P3X35_02895) 575981..576580 + 600 WP_035337155.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T275435 WP_003179128.1 NZ_CP120920:571274-571624 [Bacillus paralicheniformis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.03 Da        Isoelectric Point: 4.6920

>AT275435 WP_006638778.1 NZ_CP120920:570988-571269 [Bacillus paralicheniformis]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7FHI4

Antitoxin

Source ID Structure
AlphaFold DB M5PDU2

References