Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 36904..37649 Replicon plasmid pKPHRJ
Accession NZ_CP120848
Organism Klebsiella pneumoniae strain KPHRJ

Toxin (Protein)


Gene name tacT Uniprot ID A0A331KSM6
Locus tag P5D18_RS26665 Protein ID WP_032408901.1
Coordinates 37158..37649 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag P5D18_RS26660 Protein ID WP_014386183.1
Coordinates 36904..37170 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5D18_RS26610 (P5D18_26610) 32456..32869 - 414 WP_013023817.1 helix-turn-helix domain-containing protein -
P5D18_RS26615 (P5D18_26615) 32870..33148 - 279 WP_004152721.1 helix-turn-helix transcriptional regulator -
P5D18_RS26620 (P5D18_26620) 33138..33458 - 321 WP_014386190.1 type II toxin-antitoxin system RelE/ParE family toxin -
P5D18_RS26625 (P5D18_26625) 33539..33763 - 225 WP_014386189.1 hypothetical protein -
P5D18_RS26630 (P5D18_26630) 33774..33986 - 213 WP_014386188.1 hypothetical protein -
P5D18_RS26635 (P5D18_26635) 34048..34374 - 327 WP_014386187.1 hypothetical protein -
P5D18_RS26640 (P5D18_26640) 35011..35361 - 351 WP_014386186.1 hypothetical protein -
P5D18_RS26645 (P5D18_26645) 35358..35630 - 273 WP_032408902.1 hypothetical protein -
P5D18_RS26650 (P5D18_26650) 35820..36305 + 486 WP_014386185.1 hypothetical protein -
P5D18_RS26655 (P5D18_26655) 36549..36707 - 159 WP_014386184.1 type I toxin-antitoxin system Hok family toxin -
P5D18_RS26660 (P5D18_26660) 36904..37170 + 267 WP_014386183.1 DUF1778 domain-containing protein Antitoxin
P5D18_RS26665 (P5D18_26665) 37158..37649 + 492 WP_032408901.1 GNAT family N-acetyltransferase Toxin
P5D18_RS26670 (P5D18_26670) 38090..38341 - 252 WP_032408900.1 aldo/keto reductase -
P5D18_RS26675 (P5D18_26675) 38538..40130 - 1593 Protein_53 IS66 family transposase -
P5D18_RS26680 (P5D18_26680) 40161..40511 - 351 WP_014386180.1 IS66 family insertion sequence element accessory protein TnpB -
P5D18_RS26685 (P5D18_26685) 40508..40948 - 441 WP_014386179.1 transposase -
P5D18_RS26690 (P5D18_26690) 41210..41965 - 756 WP_032408898.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaKPC-33 / tet(A) - 1..133718 133718


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(89-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17667.46 Da        Isoelectric Point: 8.8757

>T275429 WP_032408901.1 NZ_CP120848:37158-37649 [Klebsiella pneumoniae]
VGKVTAPVPLGTSHILAEFHCGEPVLDEWIKHRGLKNQSLGAARTFVVCRGNASQVLAYYSLATGSVTHAIAPGSLRRNM
PDPVPVIILARLAVDTSYHGQGLGADLLHDAVLRCCRVAENIGVRAVMVHALSDSARQFYIHHGFIPSQTQDRTLFLRLP
LIT

Download         Length: 492 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.66 Da        Isoelectric Point: 5.1169

>AT275429 WP_014386183.1 NZ_CP120848:36904-37170 [Klebsiella pneumoniae]
MKSDVQLNIRAKEAQRALIDTAAEILHKSRTDFILEMACQAAENVILDRRMFNLNDEQYAEFIDMLDAPVTANPAMEKLL
ARKPQWAK

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A331KSM6

Antitoxin

Source ID Structure

References