Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5028721..5030402 Replicon chromosome
Accession NZ_CP120847
Organism Klebsiella pneumoniae strain KPHRJ

Toxin (Protein)


Gene name mosT Uniprot ID -
Locus tag P5D18_RS24390 Protein ID WP_004178299.1
Coordinates 5028721..5029638 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag P5D18_RS24395 Protein ID WP_004177809.1
Coordinates 5029644..5030402 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5D18_RS24370 (5024027) 5024027..5025547 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
P5D18_RS24375 (5025544) 5025544..5026542 + 999 WP_002885172.1 ribose ABC transporter permease -
P5D18_RS24380 (5026573) 5026573..5027514 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
P5D18_RS24385 (5027589) 5027589..5028596 + 1008 WP_004178300.1 carbohydrate kinase family protein -
P5D18_RS24390 (5028721) 5028721..5029638 - 918 WP_004178299.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
P5D18_RS24395 (5029644) 5029644..5030402 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
P5D18_RS24400 (5030488) 5030488..5031216 - 729 WP_004178298.1 response regulator transcription factor -
P5D18_RS24405 (5031489) 5031489..5033636 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
P5D18_RS24410 (5033633) 5033633..5033776 - 144 WP_022631365.1 hypothetical protein -
P5D18_RS24415 (5034098) 5034098..5034784 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34649.06 Da        Isoelectric Point: 5.4707

>T275427 WP_004178299.1 NZ_CP120847:c5029638-5028721 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT275427 WP_004177809.1 NZ_CP120847:c5030402-5029644 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References