Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 859399..860056 Replicon chromosome
Accession NZ_CP120847
Organism Klebsiella pneumoniae strain KPHRJ

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag P5D18_RS04290 Protein ID WP_002916310.1
Coordinates 859646..860056 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag P5D18_RS04285 Protein ID WP_002916312.1
Coordinates 859399..859665 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5D18_RS04260 (854555) 854555..855988 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
P5D18_RS04265 (856107) 856107..856835 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
P5D18_RS04270 (856885) 856885..857196 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
P5D18_RS04275 (857360) 857360..858019 + 660 WP_002916317.1 hemolysin III family protein -
P5D18_RS04280 (858170) 858170..859153 - 984 WP_020324927.1 tRNA-modifying protein YgfZ -
P5D18_RS04285 (859399) 859399..859665 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
P5D18_RS04290 (859646) 859646..860056 + 411 WP_002916310.1 protein YgfX Toxin
P5D18_RS04295 (860063) 860063..860584 - 522 WP_004144730.1 flavodoxin FldB -
P5D18_RS04300 (860685) 860685..861581 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
P5D18_RS04305 (861604) 861604..862317 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
P5D18_RS04310 (862323) 862323..864056 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T275417 WP_002916310.1 NZ_CP120847:859646-860056 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT275417 WP_002916312.1 NZ_CP120847:859399-859665 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References