Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 710596..711437 | Replicon | chromosome |
| Accession | NZ_CP120847 | ||
| Organism | Klebsiella pneumoniae strain KPHRJ | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A1M0WJM1 |
| Locus tag | P5D18_RS03530 | Protein ID | WP_000854822.1 |
| Coordinates | 711054..711437 (+) | Length | 128 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A1M0CWL2 |
| Locus tag | P5D18_RS03525 | Protein ID | WP_053271974.1 |
| Coordinates | 710596..710964 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| P5D18_RS03500 (706650) | 706650..708014 | + | 1365 | Protein_688 | autotransporter domain-containing protein | - |
| P5D18_RS03505 (708341) | 708341..709159 | + | 819 | WP_001234702.1 | DUF932 domain-containing protein | - |
| P5D18_RS03510 (709250) | 709250..709735 | + | 486 | WP_000214317.1 | antirestriction protein | - |
| P5D18_RS03515 (709750) | 709750..710226 | + | 477 | WP_001186747.1 | RadC family protein | - |
| P5D18_RS03520 (710295) | 710295..710516 | + | 222 | WP_000692312.1 | DUF987 domain-containing protein | - |
| P5D18_RS03525 (710596) | 710596..710964 | + | 369 | WP_053271974.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| P5D18_RS03530 (711054) | 711054..711437 | + | 384 | WP_000854822.1 | type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA | Toxin |
| P5D18_RS03535 (711428) | 711428..711916 | + | 489 | WP_001177592.1 | DUF5983 family protein | - |
| P5D18_RS03540 (711883) | 711883..712125 | + | 243 | WP_166635458.1 | DUF957 domain-containing protein | - |
| P5D18_RS03545 (712222) | 712222..713067 | + | 846 | WP_001280435.1 | DUF4942 domain-containing protein | - |
| P5D18_RS03555 (713366) | 713366..713872 | + | 507 | WP_002917636.1 | G/U mismatch-specific DNA glycosylase | - |
| P5D18_RS03560 (713972) | 713972..715813 | - | 1842 | WP_004174339.1 | RNA polymerase sigma factor RpoD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 128 a.a. Molecular weight: 14295.32 Da Isoelectric Point: 8.2830
>T275416 WP_000854822.1 NZ_CP120847:711054-711437 [Klebsiella pneumoniae]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHQESKRCN
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHQESKRCN
Download Length: 384 bp
Antitoxin
Download Length: 123 a.a. Molecular weight: 13679.41 Da Isoelectric Point: 6.4758
>AT275416 WP_053271974.1 NZ_CP120847:710596-710964 [Klebsiella pneumoniae]
VSDTFSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLTDRAGIRGRFSDADANHLDQAFPLLMKQLELMLTSS
ELNPHRQNTVTLYVKGLTCHADTLGSCGYVYLAVYPTPEMKN
VSDTFSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLTDRAGIRGRFSDADANHLDQAFPLLMKQLELMLTSS
ELNPHRQNTVTLYVKGLTCHADTLGSCGYVYLAVYPTPEMKN
Download Length: 369 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1M0WJM1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1M0CWL2 |