Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1388741..1389657 Replicon chromosome
Accession NZ_CP120846
Organism Bacillus atrophaeus strain MBLB1156

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A7U5BWH7
Locus tag P4829_RS07190 Protein ID WP_003327423.1
Coordinates 1388911..1389657 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID A0A837Y0B4
Locus tag P4829_RS07185 Protein ID WP_010788357.1
Coordinates 1388741..1388911 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4829_RS07150 (1385496) 1385496..1385825 + 330 WP_035175088.1 XkdW family protein -
P4829_RS07155 (1385822) 1385822..1385986 + 165 WP_063637560.1 XkdX family protein -
P4829_RS07160 (1386063) 1386063..1386911 + 849 WP_063637561.1 hypothetical protein -
P4829_RS07165 (1386985) 1386985..1387263 + 279 WP_003327427.1 hemolysin XhlA family protein -
P4829_RS07170 (1387276) 1387276..1387539 + 264 WP_003327426.1 phage holin -
P4829_RS07175 (1387552) 1387552..1388445 + 894 WP_003327425.1 N-acetylmuramoyl-L-alanine amidase -
P4829_RS07180 (1388521) 1388521..1388643 - 123 WP_010788356.1 hypothetical protein -
P4829_RS07185 (1388741) 1388741..1388911 - 171 WP_010788357.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
P4829_RS07190 (1388911) 1388911..1389657 - 747 WP_003327423.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
P4829_RS07195 (1389766) 1389766..1390764 - 999 WP_003327422.1 inorganic phosphate transporter -
P4829_RS07200 (1390777) 1390777..1391394 - 618 WP_003327421.1 DUF47 domain-containing protein -
P4829_RS07205 (1391683) 1391683..1392999 - 1317 WP_003327418.1 amino acid permease -
P4829_RS07210 (1393422) 1393422..1394372 + 951 WP_063637562.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29110.66 Da        Isoelectric Point: 4.5650

>T275414 WP_003327423.1 NZ_CP120846:c1389657-1388911 [Bacillus atrophaeus]
MLLFFQIMVWCIMAALGLYVYAVWRFEAKVKEKMFAIRKTWYLIFVIGAMVYWTYDPSSLFREWTNYLIVAVSFALIDAF
IFLSAYVKKLAGNELETDTREILEENNEMLHVYLDKLKTYQYLLKNEPIHVYYGSIEAYAEGIDKLLKTYADKMNLTASL
CEYSTQLEKDRLTEHMDDAFEVQSRLDRKDVYYDQHGKLALIPFTVQTRSYVIKLASDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6605.59 Da        Isoelectric Point: 11.0258

>AT275414 WP_010788357.1 NZ_CP120846:c1388911-1388741 [Bacillus atrophaeus]
MERAFQNDHSPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U5BWH7

Antitoxin

Source ID Structure
AlphaFold DB A0A837Y0B4

References