Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4179228..4180009 Replicon chromosome
Accession NZ_CP120837
Organism Salmonella enterica subsp. enterica strain 21A

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag P4B21_RS20455 Protein ID WP_000626100.1
Coordinates 4179228..4179719 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag P4B21_RS20460 Protein ID WP_001110452.1
Coordinates 4179716..4180009 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4B21_RS20420 (4174688) 4174688..4175035 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
P4B21_RS20425 (4175011) 4175011..4176714 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
P4B21_RS20430 (4176751) 4176751..4177326 + 576 WP_001188509.1 transcriptional regulator -
P4B21_RS20440 (4177597) 4177597..4177671 - 75 Protein_3994 helix-turn-helix domain-containing protein -
P4B21_RS20445 (4178051) 4178051..4178128 + 78 Protein_3995 porin family protein -
P4B21_RS20450 (4178228) 4178228..4178980 + 753 WP_000842433.1 non-specific acid phosphatase -
P4B21_RS20455 (4179228) 4179228..4179719 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
P4B21_RS20460 (4179716) 4179716..4180009 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
P4B21_RS20465 (4180326) 4180326..4180547 + 222 WP_001576552.1 hypothetical protein -
P4B21_RS20470 (4180813) 4180813..4181688 + 876 WP_000921676.1 AraC family transcriptional regulator -
P4B21_RS20475 (4181685) 4181685..4181972 + 288 WP_001541332.1 transcriptional regulator RtsB -
P4B21_RS20480 (4181965) 4181965..4182273 - 309 WP_072095651.1 ABC transporter ATP-binding protein -
P4B21_RS20485 (4182272) 4182272..4182520 + 249 Protein_4003 Ig-like domain-containing protein -
P4B21_RS20490 (4182632) 4182632..4182763 + 132 Protein_4004 hypothetical protein -
P4B21_RS20495 (4183057) 4183057..4183962 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T275409 WP_000626100.1 NZ_CP120837:c4179719-4179228 [Salmonella enterica subsp. enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT275409 WP_001110452.1 NZ_CP120837:c4180009-4179716 [Salmonella enterica subsp. enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References