Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4072332..4072848 Replicon chromosome
Accession NZ_CP120837
Organism Salmonella enterica subsp. enterica strain 21A

Toxin (Protein)


Gene name relE Uniprot ID B5R9I9
Locus tag P4B21_RS19880 Protein ID WP_000220582.1
Coordinates 4072332..4072616 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag P4B21_RS19885 Protein ID WP_000212724.1
Coordinates 4072606..4072848 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4B21_RS19865 (4067543) 4067543..4069195 + 1653 WP_000155048.1 alpha,alpha-phosphotrehalase -
P4B21_RS19870 (4069604) 4069604..4071742 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
P4B21_RS19875 (4071864) 4071864..4072328 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
P4B21_RS19880 (4072332) 4072332..4072616 - 285 WP_000220582.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P4B21_RS19885 (4072606) 4072606..4072848 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
P4B21_RS19890 (4072926) 4072926..4074839 - 1914 WP_001212142.1 BglG family transcription antiterminator -
P4B21_RS19895 (4074856) 4074856..4075596 - 741 WP_000779259.1 KDGP aldolase family protein -
P4B21_RS19900 (4075593) 4075593..4076711 - 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
P4B21_RS19905 (4076695) 4076695..4077828 - 1134 WP_000459957.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.66 Da        Isoelectric Point: 9.6743

>T275408 WP_000220582.1 NZ_CP120837:c4072616-4072332 [Salmonella enterica subsp. enterica]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT275408 WP_000212724.1 NZ_CP120837:c4072848-4072606 [Salmonella enterica subsp. enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656ILJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References