Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3411425..3412045 Replicon chromosome
Accession NZ_CP120837
Organism Salmonella enterica subsp. enterica strain 21A

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag P4B21_RS16810 Protein ID WP_001280991.1
Coordinates 3411827..3412045 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag P4B21_RS16805 Protein ID WP_000344807.1
Coordinates 3411425..3411799 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4B21_RS16795 (3406564) 3406564..3407757 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P4B21_RS16800 (3407780) 3407780..3410929 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
P4B21_RS16805 (3411425) 3411425..3411799 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
P4B21_RS16810 (3411827) 3411827..3412045 + 219 WP_001280991.1 HHA domain-containing protein Toxin
P4B21_RS16815 (3412224) 3412224..3412775 + 552 WP_001278793.1 maltose O-acetyltransferase -
P4B21_RS16820 (3412893) 3412893..3413363 + 471 WP_000136183.1 YlaC family protein -
P4B21_RS16825 (3413419) 3413419..3413559 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
P4B21_RS16830 (3413565) 3413565..3413825 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
P4B21_RS16835 (3414050) 3414050..3415600 + 1551 WP_000213140.1 EAL domain-containing protein -
P4B21_RS16845 (3415831) 3415831..3416220 + 390 WP_000961287.1 MGMT family protein -
P4B21_RS16850 (3416253) 3416253..3416822 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T275403 WP_001280991.1 NZ_CP120837:3411827-3412045 [Salmonella enterica subsp. enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT275403 WP_000344807.1 NZ_CP120837:3411425-3411799 [Salmonella enterica subsp. enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References