Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 191594..192233 Replicon chromosome
Accession NZ_CP120733
Organism Tepidibacter sp. SWIR-1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag P4S50_RS00755 Protein ID WP_277732602.1
Coordinates 191871..192233 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag P4S50_RS00750 Protein ID WP_277732601.1
Coordinates 191594..191878 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4S50_RS00720 (P4S50_00720) 186608..186802 + 195 WP_277732595.1 hypothetical protein -
P4S50_RS00725 (P4S50_00725) 186823..188796 + 1974 WP_277732596.1 methyl-accepting chemotaxis protein -
P4S50_RS00730 (P4S50_00730) 188944..189330 + 387 WP_277732597.1 holo-ACP synthase -
P4S50_RS00735 (P4S50_00735) 189333..189782 + 450 WP_277732598.1 CBS domain-containing protein -
P4S50_RS00740 (P4S50_00740) 189800..190384 + 585 WP_277732599.1 germination lipoprotein GerS -
P4S50_RS00745 (P4S50_00745) 190404..191564 + 1161 WP_277732600.1 alanine racemase -
P4S50_RS00750 (P4S50_00750) 191594..191878 + 285 WP_277732601.1 ribbon-helix-helix protein, CopG family Antitoxin
P4S50_RS00755 (P4S50_00755) 191871..192233 + 363 WP_277732602.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
P4S50_RS00760 (P4S50_00760) 192392..192904 + 513 WP_277732603.1 hypothetical protein -
P4S50_RS00765 (P4S50_00765) 193439..195499 + 2061 WP_277732604.1 DUF5693 family protein -
P4S50_RS00770 (P4S50_00770) 195492..196616 + 1125 WP_277732605.1 polysaccharide pyruvyl transferase CsaB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-46)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13407.44 Da        Isoelectric Point: 5.8864

>T275387 WP_277732602.1 NZ_CP120733:191871-192233 [Tepidibacter sp. SWIR-1]
VNKNLEIKRGDIFYGDLSPVIGSEQGGVRPVLIIQNDIGNKYSPTVIIAAITSQINKAKLPTHIEINANDYGLNRDSVVL
LEQVRTIDKKRLREKIGNFDEDMMKKVDEGLQISLGLFDI

Download         Length: 363 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10610.38 Da        Isoelectric Point: 7.9578

>AT275387 WP_277732601.1 NZ_CP120733:191594-191878 [Tepidibacter sp. SWIR-1]
VSSCVDKKKIVVSLPNSLLSEVDKIIKVENKNRSEFIKEAMNLYLREKRKVQTRESMIKGYREMGVINLALAEMGLSIDM
SSLEGYEGKIAEGE

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References