Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 1283747..1284384 Replicon chromosome
Accession NZ_CP120730
Organism Burkholderia vietnamiensis strain LMG16232

Toxin (Protein)


Gene name vapC Uniprot ID I2DIN1
Locus tag P4G95_RS05890 Protein ID WP_014722201.1
Coordinates 1283983..1284384 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag P4G95_RS05885 Protein ID WP_011882846.1
Coordinates 1283747..1283983 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4G95_RS05870 (P4G95_05870) 1279286..1280320 + 1035 WP_034192975.1 helix-turn-helix domain-containing protein -
P4G95_RS05875 (P4G95_05875) 1280647..1281768 - 1122 WP_131753316.1 ADP-heptose--LPS heptosyltransferase -
P4G95_RS05880 (P4G95_05880) 1281765..1283468 - 1704 WP_059669504.1 thiamine pyrophosphate-binding protein -
P4G95_RS05885 (P4G95_05885) 1283747..1283983 + 237 WP_011882846.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
P4G95_RS05890 (P4G95_05890) 1283983..1284384 + 402 WP_014722201.1 type II toxin-antitoxin system VapC family toxin Toxin
P4G95_RS05895 (P4G95_05895) 1284452..1285840 - 1389 WP_014722202.1 L-serine ammonia-lyase -
P4G95_RS05900 (P4G95_05900) 1285871..1287007 - 1137 WP_045578623.1 alginate lyase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-119)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14908.05 Da        Isoelectric Point: 5.1684

>T275382 WP_014722201.1 NZ_CP120730:1283983-1284384 [Burkholderia vietnamiensis]
MPRYMLDTNMCIYLMKSQPEQVAKRFAQCYTGDVVMSAITYAELEYGVTACAAPARERRHLAALIEDIPVAPFDAAAAQA
YGPVRDATRAWKKDHLDKLIAAHAVSLDVVLVTNDERDFTSYPGLRLENWLND

Download         Length: 402 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9021.21 Da        Isoelectric Point: 7.2056

>AT275382 WP_011882846.1 NZ_CP120730:1283747-1283983 [Burkholderia vietnamiensis]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERIGDEIRIRPARRPLTQVLKKFAKFAPDFMAEGRGDHEQAEREGL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I2DIN1

Antitoxin

Source ID Structure

References