Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1385248..1386164 Replicon chromosome
Accession NZ_CP120723
Organism Bacillus atrophaeus strain NX-12

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag P3T49_RS07160 Protein ID WP_106359718.1
Coordinates 1385418..1386164 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID -
Locus tag P3T49_RS07155 Protein ID WP_106359719.1
Coordinates 1385248..1385418 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P3T49_RS07120 (1382004) 1382004..1382333 + 330 WP_088116995.1 XkdW family protein -
P3T49_RS07125 (1382330) 1382330..1382494 + 165 WP_061571316.1 XkdX family protein -
P3T49_RS07130 (1382571) 1382571..1383419 + 849 WP_277714599.1 phage portal protein -
P3T49_RS07135 (1383492) 1383492..1383770 + 279 WP_003327427.1 hemolysin XhlA family protein -
P3T49_RS07140 (1383783) 1383783..1384046 + 264 WP_003327426.1 phage holin -
P3T49_RS07145 (1384059) 1384059..1384952 + 894 WP_003327425.1 N-acetylmuramoyl-L-alanine amidase -
P3T49_RS07150 (1385028) 1385028..1385150 - 123 WP_010788356.1 hypothetical protein -
P3T49_RS07155 (1385248) 1385248..1385418 - 171 WP_106359719.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
P3T49_RS07160 (1385418) 1385418..1386164 - 747 WP_106359718.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
P3T49_RS07165 (1386273) 1386273..1387271 - 999 WP_003327422.1 inorganic phosphate transporter -
P3T49_RS07170 (1387284) 1387284..1387901 - 618 WP_003327421.1 DUF47 domain-containing protein -
P3T49_RS07175 (1388189) 1388189..1389505 - 1317 WP_003327418.1 amino acid permease -
P3T49_RS07180 (1389925) 1389925..1390875 + 951 WP_277714600.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29092.63 Da        Isoelectric Point: 4.5650

>T275381 WP_106359718.1 NZ_CP120723:c1386164-1385418 [Bacillus atrophaeus]
MLLFFQIIVWCIMAALGLYVYAVWRFEAKVKEKMFAIRKTWYLIFVIGAMVYWTYDPSSLFREWTNYLIVAVSFALIDAF
IFLSAYVKKLAGNELETDTREILEENNEMLHVYLDKLKTYQYLLKNEPIHVYYGSIEAYAEGIDKLLKTYADKMNLTASL
CEYSTQLEKDRLTEHMDDAFEVQSRLDRKDVYYDQHGKLALIPFTVQTRSYVIKLASDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6617.64 Da        Isoelectric Point: 11.0258

>AT275381 WP_106359719.1 NZ_CP120723:c1385418-1385248 [Bacillus atrophaeus]
MERAFQNDHSPRAAKPFKILKKRSITSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References