Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 5902980..5903615 Replicon chromosome
Accession NZ_CP120718
Organism Paenibacillus sp. BR1-192

Toxin (Protein)


Gene name mazF Uniprot ID W4ARZ2
Locus tag P0X86_RS26820 Protein ID WP_006212388.1
Coordinates 5902980..5903330 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A1S2F0P6
Locus tag P0X86_RS26825 Protein ID WP_028406492.1
Coordinates 5903334..5903615 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0X86_RS26795 (P0X86_26795) 5898301..5898651 + 351 WP_009594449.1 hypothetical protein -
P0X86_RS26800 (P0X86_26800) 5898732..5898863 + 132 WP_015737250.1 cortex morphogenetic protein CmpA -
P0X86_RS26805 (P0X86_26805) 5898961..5899431 - 471 WP_213579677.1 DinB family protein -
P0X86_RS26810 (P0X86_26810) 5899576..5900136 + 561 WP_277746901.1 CGNR zinc finger domain-containing protein -
P0X86_RS26815 (P0X86_26815) 5900341..5902557 - 2217 WP_277746902.1 Tex family protein -
P0X86_RS26820 (P0X86_26820) 5902980..5903330 - 351 WP_006212388.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
P0X86_RS26825 (P0X86_26825) 5903334..5903615 - 282 WP_028406492.1 ribbon-helix-helix protein, CopG family Antitoxin
P0X86_RS26830 (P0X86_26830) 5903842..5905029 - 1188 WP_213579679.1 alanine racemase -
P0X86_RS26835 (P0X86_26835) 5905302..5906414 - 1113 WP_096776514.1 outer membrane lipoprotein-sorting protein -
P0X86_RS26840 (P0X86_26840) 5906678..5908006 - 1329 WP_192570688.1 MFS transporter -
P0X86_RS26845 (P0X86_26845) 5908069..5908569 - 501 WP_277746903.1 winged helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-46)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12751.64 Da        Isoelectric Point: 4.8265

>T275376 WP_006212388.1 NZ_CP120718:c5903330-5902980 [Paenibacillus sp. BR1-192]
VIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAASHGFDRDSVILLEQI
RTIDKQRLTDKITHLDDEMMSKVDDSLQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10784.35 Da        Isoelectric Point: 6.4708

>AT275376 WP_028406492.1 NZ_CP120718:c5903615-5903334 [Paenibacillus sp. BR1-192]
VANMQNTKRIMISLPDHLLQEVDGIAQLENSNRSELIRQAMKLYLNERKKRYIRESMQRGYMEMAKINLTMASEAFHAEE
DADNTLDRLVSGV

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S2EZN8

Antitoxin

Source ID Structure
AlphaFold DB A0A1S2F0P6

References