275375

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 3882782..3883699 Replicon chromosome
Accession NZ_CP120711
Organism Bacillus velezensis strain 12Y

Toxin (Protein)


Gene name spoIISA Uniprot ID I2HQ15
Locus tag P0M29_RS20120 Protein ID WP_007407256.1
Coordinates 3882953..3883699 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag P0M29_RS20115 Protein ID WP_003154807.1
Coordinates 3882782..3882952 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0M29_RS20075 (3877994) 3877994..3879583 + 1590 WP_029973066.1 hypothetical protein -
P0M29_RS20080 (3879596) 3879596..3880021 + 426 WP_029973065.1 hypothetical protein -
P0M29_RS20085 (3880026) 3880026..3880223 + 198 WP_007610833.1 XkdX family protein -
P0M29_RS20090 (3880280) 3880280..3881041 + 762 WP_029973064.1 hypothetical protein -
P0M29_RS20095 (3881093) 3881093..3881356 + 264 WP_003154815.1 hemolysin XhlA family protein -
P0M29_RS20100 (3881370) 3881370..3881633 + 264 WP_003154813.1 phage holin -
P0M29_RS20105 (3881647) 3881647..3882525 + 879 WP_007407257.1 N-acetylmuramoyl-L-alanine amidase -
P0M29_RS20110 (3882560) 3882560..3882685 - 126 WP_003154809.1 hypothetical protein -
P0M29_RS20115 (3882782) 3882782..3882952 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
P0M29_RS20120 (3882953) 3882953..3883699 - 747 WP_007407256.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
P0M29_RS20125 (3883803) 3883803..3884801 - 999 WP_003154805.1 inorganic phosphate transporter -
P0M29_RS20130 (3884814) 3884814..3885431 - 618 WP_003154804.1 DUF47 domain-containing protein -
P0M29_RS20135 (3885717) 3885717..3887033 - 1317 WP_007610842.1 amino acid permease -
P0M29_RS20140 (3887355) 3887355..3888305 + 951 WP_007610844.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29077.57 Da        Isoelectric Point: 4.7755

>T275375 WP_007407256.1 NZ_CP120711:c3883699-3882953 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT275375 WP_003154807.1 NZ_CP120711:c3882952-3882782 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I2HQ15

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References