275348

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1441826..1442738 Replicon chromosome
Accession NZ_CP120679
Organism Bacillus sp. HSf4

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A6I7FAV9
Locus tag P3X63_RS07400 Protein ID WP_026586617.1
Coordinates 1441992..1442738 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID A0A6I7F9D9
Locus tag P3X63_RS07395 Protein ID WP_026586616.1
Coordinates 1441826..1441990 (-) Length 55 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P3X63_RS07370 (P3X63_07370) 1437267..1438364 + 1098 WP_026586613.1 mannonate dehydratase -
P3X63_RS07375 (P3X63_07375) 1438340..1439188 + 849 WP_277692675.1 SDR family oxidoreductase -
P3X63_RS07380 (P3X63_07380) 1439210..1440223 + 1014 WP_277692676.1 zinc-binding alcohol dehydrogenase family protein -
P3X63_RS07385 (P3X63_07385) 1440277..1441548 + 1272 WP_277692677.1 MFS transporter -
P3X63_RS07390 (P3X63_07390) 1441609..1441737 - 129 WP_256860446.1 hypothetical protein -
P3X63_RS07395 (P3X63_07395) 1441826..1441990 - 165 WP_026586616.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
P3X63_RS07400 (P3X63_07400) 1441992..1442738 - 747 WP_026586617.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
P3X63_RS07405 (P3X63_07405) 1442848..1443846 - 999 WP_026586618.1 inorganic phosphate transporter -
P3X63_RS07410 (P3X63_07410) 1443859..1444476 - 618 WP_026586619.1 DUF47 domain-containing protein -
P3X63_RS07415 (P3X63_07415) 1444809..1446560 + 1752 WP_277692678.1 gamma-glutamyltransferase -
P3X63_RS07420 (P3X63_07420) 1446696..1447340 + 645 WP_026586621.1 YesL family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-54)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29298.67 Da        Isoelectric Point: 4.6449

>T275348 WP_026586617.1 NZ_CP120679:c1442738-1441992 [Bacillus sp. HSf4]
MLLFYQFLVWLIVLALALYVAAVWRFEKKLTEKTVAIRKTWYLLYVIGAVIYWTHDPQSIFTNPLHYLIVAVFFTLTDAF
IFLNAYFKKLGSSELATDTRMLLEENNDLLHTYQNRLKTYQYLLKNEPIHIYYGSIEAYAEGIEKLISRFGEKMNISAAL
CEYNSNESKDHLLEHMENRFAVQEKLDRKDVYYEENGKMVLIPFSIHDYDYVMKLTSEDLVTEFDYLLFTSLTSVYDLLL
PNEEEGDD

Download         Length: 747 bp

Antitoxin


Download         Length: 55 a.a.        Molecular weight: 6505.61 Da        Isoelectric Point: 10.9064

>AT275348 WP_026586616.1 NZ_CP120679:c1441990-1441826 [Bacillus sp. HSf4]
MEPAFQENAKKRLSFKMFKKQSKTSIAKYEVSPHTERIFKQNERLIGEYKRKKA

Download         Length: 165 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7FAV9

Antitoxin

Source ID Structure
AlphaFold DB A0A6I7F9D9

References