Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 2114766..2115337 Replicon chromosome
Accession NZ_CP120677
Organism Tissierella sp. Yu-01

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag P3962_RS10830 Protein ID WP_277719457.1
Coordinates 2115005..2115337 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag P3962_RS10825 Protein ID WP_277719456.1
Coordinates 2114766..2115005 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P3962_RS10805 (P3962_10805) 2111227..2111469 - 243 WP_277719452.1 hypothetical protein -
P3962_RS10810 (P3962_10810) 2111628..2112629 - 1002 WP_277719453.1 ATP-binding cassette domain-containing protein -
P3962_RS10815 (P3962_10815) 2112622..2113323 - 702 WP_277719454.1 GTP-binding protein -
P3962_RS10820 (P3962_10820) 2113336..2114568 - 1233 WP_277719455.1 ABC transporter substrate-binding protein -
P3962_RS10825 (P3962_10825) 2114766..2115005 + 240 WP_277719456.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
P3962_RS10830 (P3962_10830) 2115005..2115337 + 333 WP_277719457.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
P3962_RS10835 (P3962_10835) 2115405..2115791 + 387 WP_277719458.1 DUF302 domain-containing protein -
P3962_RS10840 (P3962_10840) 2115842..2117128 - 1287 WP_277719459.1 copper amine oxidase N-terminal domain-containing protein -
P3962_RS10845 (P3962_10845) 2117292..2117474 - 183 WP_277719460.1 hypothetical protein -
P3962_RS10850 (P3962_10850) 2117541..2117783 - 243 WP_277719461.1 DUF2249 domain-containing protein -
P3962_RS10855 (P3962_10855) 2118124..2118708 - 585 WP_277719462.1 accessory gene regulator B family protein -
P3962_RS10860 (P3962_10860) 2119277..2120215 - 939 WP_277719463.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-105)

Antitoxin

SpoVT-AbrB domain

(6-50)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12600.52 Da        Isoelectric Point: 5.7225

>T275346 WP_277719457.1 NZ_CP120677:2115005-2115337 [Tissierella sp. Yu-01]
MTYIPEQGDIIFIEFNPQVGHEQKGKRPALVVSNYTFNKFTKLAMLCPITNTDRSFPLHVKLDERTKTTGVIMCEQVKSL
DYNARAISFYERSPEDIVAEVKDVLLGFIE

Download         Length: 333 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9175.47 Da        Isoelectric Point: 5.6235

>AT275346 WP_277719456.1 NZ_CP120677:2114766-2115005 [Tissierella sp. Yu-01]
MFTTIQKWGNSQAVRIPKAILEMANLRENDNVELRVHEGNLLIIPVKKHKSLEQRIAEYEGEYHCSEWETSDPIGKEVL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References