Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 4165405..4165927 Replicon chromosome
Accession NZ_CP120671
Organism Salmonella enterica strain SC2020597

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag P4B13_RS20075 Protein ID WP_000221343.1
Coordinates 4165405..4165689 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag P4B13_RS20080 Protein ID WP_000885424.1
Coordinates 4165679..4165927 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4B13_RS20055 (4161480) 4161480..4162988 - 1509 WP_017465709.1 FAD-dependent oxidoreductase -
P4B13_RS20060 (4163033) 4163033..4163521 + 489 WP_017465710.1 MarR family winged helix-turn-helix transcriptional regulator -
P4B13_RS20065 (4163714) 4163714..4164793 + 1080 WP_017465711.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
P4B13_RS20070 (4164845) 4164845..4165234 - 390 WP_000194089.1 RidA family protein -
P4B13_RS20075 (4165405) 4165405..4165689 - 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P4B13_RS20080 (4165679) 4165679..4165927 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
P4B13_RS20085 (4166075) 4166075..4166530 - 456 Protein_3913 helix-turn-helix domain-containing protein -
P4B13_RS20090 (4166883) 4166883..4167173 - 291 WP_000742001.1 hypothetical protein -
P4B13_RS20095 (4167475) 4167475..4168941 - 1467 WP_000987828.1 hypothetical protein -
P4B13_RS20100 (4169199) 4169199..4170206 + 1008 WP_000201074.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4160043..4168938 8895


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T275341 WP_000221343.1 NZ_CP120671:c4165689-4165405 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT275341 WP_000885424.1 NZ_CP120671:c4165927-4165679 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References