Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3117445..3118065 Replicon chromosome
Accession NZ_CP120671
Organism Salmonella enterica strain SC2020597

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag P4B13_RS14830 Protein ID WP_001280991.1
Coordinates 3117445..3117663 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag P4B13_RS14835 Protein ID WP_000344807.1
Coordinates 3117691..3118065 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4B13_RS14790 (3112668) 3112668..3113237 + 570 WP_000779802.1 YbaY family lipoprotein -
P4B13_RS14795 (3113270) 3113270..3113659 - 390 WP_000961285.1 MGMT family protein -
P4B13_RS14805 (3113890) 3113890..3115440 - 1551 WP_000213139.1 EAL domain-containing protein -
P4B13_RS14810 (3115665) 3115665..3115925 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
P4B13_RS14815 (3115931) 3115931..3116071 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
P4B13_RS14820 (3116127) 3116127..3116597 - 471 WP_000136183.1 YlaC family protein -
P4B13_RS14825 (3116715) 3116715..3117266 - 552 WP_001278793.1 maltose O-acetyltransferase -
P4B13_RS14830 (3117445) 3117445..3117663 - 219 WP_001280991.1 HHA domain-containing protein Toxin
P4B13_RS14835 (3117691) 3117691..3118065 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
P4B13_RS14840 (3118561) 3118561..3121710 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
P4B13_RS14845 (3121733) 3121733..3122926 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T275340 WP_001280991.1 NZ_CP120671:c3117663-3117445 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT275340 WP_000344807.1 NZ_CP120671:c3118065-3117691 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References