Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2408904..2409420 Replicon chromosome
Accession NZ_CP120671
Organism Salmonella enterica strain SC2020597

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag P4B13_RS11535 Protein ID WP_000220578.1
Coordinates 2409136..2409420 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag P4B13_RS11530 Protein ID WP_000212724.1
Coordinates 2408904..2409146 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4B13_RS11510 (2403924) 2403924..2405057 + 1134 WP_017465838.1 amidohydrolase/deacetylase family metallohydrolase -
P4B13_RS11515 (2405041) 2405041..2406159 + 1119 WP_017465839.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
P4B13_RS11520 (2406156) 2406156..2406896 + 741 WP_023193113.1 KDGP aldolase family protein -
P4B13_RS11525 (2406913) 2406913..2408826 + 1914 WP_001212135.1 BglG family transcription antiterminator -
P4B13_RS11530 (2408904) 2408904..2409146 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
P4B13_RS11535 (2409136) 2409136..2409420 + 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P4B13_RS11540 (2409424) 2409424..2409888 - 465 WP_017465840.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
P4B13_RS11545 (2410105) 2410105..2412243 - 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
P4B13_RS11550 (2412652) 2412652..2414304 - 1653 WP_000155049.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T275337 WP_000220578.1 NZ_CP120671:2409136-2409420 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT275337 WP_000212724.1 NZ_CP120671:2408904-2409146 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References