Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1782217..1783840 Replicon chromosome
Accession NZ_CP120671
Organism Salmonella enterica strain SC2020597

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag P4B13_RS08485 Protein ID WP_000088046.1
Coordinates 1782515..1783840 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag P4B13_RS08480 Protein ID WP_024136327.1
Coordinates 1782217..1782510 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4B13_RS08450 (1778089) 1778089..1779330 + 1242 WP_001053338.1 VWA domain-containing protein -
P4B13_RS08455 (1779421) 1779421..1779552 + 132 WP_000374059.1 hypothetical protein -
P4B13_RS08460 (1779893) 1779893..1780174 - 282 WP_000077926.1 hypothetical protein -
P4B13_RS08465 (1780224) 1780224..1780415 - 192 WP_000398480.1 hypothetical protein -
P4B13_RS08470 (1780507) 1780507..1780848 - 342 WP_001151575.1 hypothetical protein -
P4B13_RS08475 (1781221) 1781221..1781613 + 393 WP_000341066.1 hypothetical protein -
P4B13_RS08480 (1782217) 1782217..1782510 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
P4B13_RS08485 (1782515) 1782515..1783840 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
P4B13_RS08490 (1783901) 1783901..1784107 + 207 WP_000134171.1 hypothetical protein -
P4B13_RS08495 (1784209) 1784209..1784619 + 411 WP_000985911.1 hypothetical protein -
P4B13_RS08500 (1784632) 1784632..1785447 + 816 WP_053276223.1 HNH endonuclease signature motif containing protein -
P4B13_RS08505 (1785701) 1785701..1786126 + 426 WP_001043843.1 hypothetical protein -
P4B13_RS08510 (1786669) 1786669..1787366 + 698 WP_095033700.1 IS1-like element IS1B family transposase -
P4B13_RS08515 (1788300) 1788300..1788575 + 276 WP_001141270.1 formaldehyde-responsive transcriptional repressor FrmR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(A) / dfrA12 / aadA2 / qacE / sul1 / sul4 / mph(E) / msr(E) / mph(A) / blaDHA-1 / qnrB4 / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr / sul2 / aph(3'')-Ib / aph(6)-Id / floR - 1599852..2011007 411155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T275336 WP_000088046.1 NZ_CP120671:1782515-1783840 [Salmonella enterica]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT275336 WP_024136327.1 NZ_CP120671:1782217-1782510 [Salmonella enterica]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References