Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1232089..1232849 Replicon chromosome
Accession NZ_CP120671
Organism Salmonella enterica strain SC2020597

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag P4B13_RS05830 Protein ID WP_000533909.1
Coordinates 1232089..1232574 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag P4B13_RS05835 Protein ID WP_000965886.1
Coordinates 1232562..1232849 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4B13_RS05800 (1227159) 1227159..1227821 + 663 WP_000747548.1 OmpA family lipoprotein -
P4B13_RS05805 (1228040) 1228040..1229014 + 975 WP_017465308.1 glyoxylate/hydroxypyruvate reductase GhrB -
P4B13_RS05810 (1229064) 1229064..1229774 - 711 WP_000190524.1 DUF3053 domain-containing protein -
P4B13_RS05815 (1230213) 1230213..1230503 + 291 WP_000455790.1 HTH-type transcriptional regulator -
P4B13_RS05820 (1230791) 1230791..1231003 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
P4B13_RS05825 (1231176) 1231176..1231715 + 540 WP_000047140.1 copper-binding periplasmic metallochaperone CueP -
P4B13_RS05830 (1232089) 1232089..1232574 - 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
P4B13_RS05835 (1232562) 1232562..1232849 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
P4B13_RS05840 (1233027) 1233027..1233494 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
P4B13_RS05845 (1233666) 1233666..1234064 - 399 Protein_1133 IS3 family transposase -
P4B13_RS05850 (1234454) 1234454..1236523 - 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
P4B13_RS05855 (1236533) 1236533..1237444 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T275333 WP_000533909.1 NZ_CP120671:c1232574-1232089 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT275333 WP_000965886.1 NZ_CP120671:c1232849-1232562 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References