Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 591578..592203 Replicon chromosome
Accession NZ_CP120671
Organism Salmonella enterica strain SC2020597

Toxin (Protein)


Gene name vapC Uniprot ID A0A5I5T1K0
Locus tag P4B13_RS02685 Protein ID WP_001748684.1
Coordinates 591578..591976 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C0PXM4
Locus tag P4B13_RS02690 Protein ID WP_000557545.1
Coordinates 591976..592203 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4B13_RS02670 (588251) 588251..588838 - 588 WP_001244643.1 fimbrial protein -
P4B13_RS02675 (589557) 589557..590189 - 633 WP_000835265.1 YfdX family protein -
P4B13_RS02680 (590236) 590236..590772 - 537 WP_017465475.1 STM3031 family outer membrane protein -
P4B13_RS02685 (591578) 591578..591976 - 399 WP_001748684.1 tRNA(fMet)-specific endonuclease VapC Toxin
P4B13_RS02690 (591976) 591976..592203 - 228 WP_000557545.1 toxin-antitoxin system antitoxin VapB Antitoxin
P4B13_RS02695 (592412) 592412..592663 + 252 WP_001748683.1 hypothetical protein -
P4B13_RS02700 (592938) 592938..593744 + 807 WP_077907190.1 DUF1460 domain-containing protein -
P4B13_RS02710 (594029) 594029..594787 - 759 WP_000244328.1 amidase activator ActS -
P4B13_RS02715 (595052) 595052..595597 + 546 WP_000133986.1 isopentenyl-diphosphate Delta-isomerase -
P4B13_RS02720 (595673) 595673..597190 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14995.39 Da        Isoelectric Point: 7.7780

>T275330 WP_001748684.1 NZ_CP120671:c591976-591578 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHVKERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8500.48 Da        Isoelectric Point: 5.0053

>AT275330 WP_000557545.1 NZ_CP120671:c592203-591976 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I5T1K0

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9MGW6

References