Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 434564..435378 Replicon chromosome
Accession NZ_CP120671
Organism Salmonella enterica strain SC2020597

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag P4B13_RS01980 Protein ID WP_000971655.1
Coordinates 434851..435378 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag P4B13_RS01975 Protein ID WP_000855694.1
Coordinates 434564..434854 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4B13_RS01945 (430515) 430515..431165 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
P4B13_RS01950 (431621) 431621..432064 + 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
P4B13_RS01955 (432495) 432495..432944 + 450 WP_000381612.1 membrane protein -
P4B13_RS01960 (432929) 432929..433276 + 348 WP_023198553.1 DUF1493 family protein -
P4B13_RS01965 (433549) 433549..433875 - 327 WP_000393302.1 hypothetical protein -
P4B13_RS01970 (434116) 434116..434294 + 179 Protein_377 IS3 family transposase -
P4B13_RS01975 (434564) 434564..434854 + 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
P4B13_RS01980 (434851) 434851..435378 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
P4B13_RS01985 (435451) 435451..435860 - 410 Protein_380 IS5/IS1182 family transposase -
P4B13_RS01990 (436093) 436093..436749 + 657 WP_001748710.1 protein-serine/threonine phosphatase -
P4B13_RS01995 (436994) 436994..437488 - 495 WP_000424947.1 hypothetical protein -
P4B13_RS02000 (437515) 437515..438183 - 669 WP_000445914.1 hypothetical protein -
P4B13_RS02005 (438340) 438340..438579 - 240 Protein_384 hypothetical protein -
P4B13_RS02010 (438770) 438770..439168 - 399 Protein_385 cytoplasmic protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 435451..435591 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T275329 WP_000971655.1 NZ_CP120671:434851-435378 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT275329 WP_000855694.1 NZ_CP120671:434564-434854 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References