Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | omega-epsilon-zeta/zeta-couple_hipB |
| Location | 690464..691707 | Replicon | chromosome |
| Accession | NZ_CP120654 | ||
| Organism | Streptococcus agalactiae strain Guangzhou-SAG036 | ||
Toxin (Protein)
| Gene name | sezT | Uniprot ID | G7SEB4 |
| Locus tag | P3L36_RS03860 | Protein ID | WP_001235242.1 |
| Coordinates | 690940..691707 (+) | Length | 256 a.a. |
Antitoxin (Protein)
| Gene name | sezA | Uniprot ID | - |
| Locus tag | P3L36_RS03855 | Protein ID | WP_000578719.1 |
| Coordinates | 690464..690940 (+) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| P3L36_RS03830 (P3L36_03830) | 686557..688248 | + | 1692 | WP_050547274.1 | recombinase family protein | - |
| P3L36_RS03835 (P3L36_03835) | 688312..689412 | + | 1101 | WP_000196859.1 | toprim domain-containing protein | - |
| P3L36_RS03840 (P3L36_03840) | 689440..689667 | + | 228 | WP_000110922.1 | DUF5965 family protein | - |
| P3L36_RS03845 (P3L36_03845) | 689664..690053 | + | 390 | WP_000048066.1 | DUF5945 family protein | - |
| P3L36_RS03850 (P3L36_03850) | 690104..690394 | + | 291 | WP_000667951.1 | hypothetical protein | - |
| P3L36_RS03855 (P3L36_03855) | 690464..690940 | + | 477 | WP_000578719.1 | type II toxin-antitoxin system antitoxin PezA | Antitoxin |
| P3L36_RS03860 (P3L36_03860) | 690940..691707 | + | 768 | WP_001235242.1 | type II toxin-antitoxin system toxin PezT | Toxin |
| P3L36_RS03865 (P3L36_03865) | 691708..694251 | + | 2544 | WP_000601012.1 | AAA family ATPase | - |
| P3L36_RS03870 (P3L36_03870) | 694589..694951 | + | 363 | WP_000140674.1 | SAG1252 family conjugative relaxosome accessory protein | - |
| P3L36_RS03875 (P3L36_03875) | 694954..695319 | + | 366 | WP_000431640.1 | MobC family plasmid mobilization relaxosome protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | tet(O) / ant(6)-Ia / aph(3')-III / erm(B) | cylX / cylD / cylG / acpC / cylZ / cylA / cylB / cylE / cylF / cylI / cylJ / cylK | 611846..727472 | 115626 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 256 a.a. Molecular weight: 28985.80 Da Isoelectric Point: 5.1126
>T275328 WP_001235242.1 NZ_CP120654:690940-691707 [Streptococcus agalactiae]
MRLEEFSEAEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEQLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELESENLFDQIQIYQRDRTCIYDSETAEGSAAEVLQECLFGKWSKVEEEMV
KESELLLKELLEKNK
MRLEEFSEAEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEQLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELESENLFDQIQIYQRDRTCIYDSETAEGSAAEVLQECLFGKWSKVEEEMV
KESELLLKELLEKNK
Download Length: 768 bp
Antitoxin
Download Length: 159 a.a. Molecular weight: 18266.77 Da Isoelectric Point: 4.6424
>AT275328 WP_000578719.1 NZ_CP120654:690464-690940 [Streptococcus agalactiae]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSKLYRYQDSQDIVFDDESNPWILMSDDLAELINTKIYLVATFDEIERYNGYLDGIERMLDMVHHRVVA
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSKLYRYQDSQDIVFDDESNPWILMSDDLAELINTKIYLVATFDEIERYNGYLDGIERMLDMVHHRVVA
Download Length: 477 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|