Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Xre-MNT/HTH_26(antitoxin) |
Location | 672598..673706 | Replicon | chromosome |
Accession | NZ_CP120654 | ||
Organism | Streptococcus agalactiae strain Guangzhou-SAG036 |
Toxin (Protein)
Gene name | MNTss | Uniprot ID | A0A3S8RBH6 |
Locus tag | P3L36_RS03730 | Protein ID | WP_071661597.1 |
Coordinates | 672837..673706 (+) | Length | 290 a.a. |
Antitoxin (Protein)
Gene name | Xress | Uniprot ID | - |
Locus tag | P3L36_RS03725 | Protein ID | WP_277687628.1 |
Coordinates | 672598..672822 (+) | Length | 75 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
P3L36_RS03690 (P3L36_03690) | 667814..667984 | + | 171 | WP_004614788.1 | cysteine-rich KTR domain-containing protein | - |
P3L36_RS03695 (P3L36_03695) | 668187..668357 | + | 171 | WP_000713595.1 | hypothetical protein | - |
P3L36_RS03700 (P3L36_03700) | 668371..668973 | + | 603 | WP_001062586.1 | recombinase family protein | - |
P3L36_RS03705 (P3L36_03705) | 668989..669666 | + | 678 | Protein_646 | DNA topoisomerase | - |
P3L36_RS03710 (P3L36_03710) | 669977..670474 | + | 498 | WP_002327635.1 | DNA recombinase | - |
P3L36_RS03715 (P3L36_03715) | 670475..670891 | + | 417 | WP_000323438.1 | recombinase | - |
P3L36_RS03720 (P3L36_03720) | 670911..672455 | + | 1545 | WP_002390960.1 | recombinase family protein | - |
P3L36_RS03725 (P3L36_03725) | 672598..672822 | + | 225 | WP_277687628.1 | helix-turn-helix transcriptional regulator | Antitoxin |
P3L36_RS03730 (P3L36_03730) | 672837..673706 | + | 870 | WP_071661597.1 | nucleotidyltransferase domain-containing protein | Toxin |
P3L36_RS03735 (P3L36_03735) | 673687..674421 | + | 735 | WP_000662263.1 | class I SAM-dependent methyltransferase | - |
P3L36_RS03740 (P3L36_03740) | 674454..675362 | + | 909 | WP_001255866.1 | aminoglycoside nucleotidyltransferase ANT(6)-Ia | - |
P3L36_RS03745 (P3L36_03745) | 675359..675559 | + | 201 | Protein_654 | hypothetical protein | - |
P3L36_RS03750 (P3L36_03750) | 675639..676801 | + | 1163 | WP_088186165.1 | IS3-like element ISSag12 family transposase | - |
P3L36_RS03755 (P3L36_03755) | 676960..677211 | + | 252 | Protein_656 | GNAT family N-acetyltransferase | - |
P3L36_RS03760 (P3L36_03760) | 677304..678098 | + | 795 | WP_001096887.1 | aminoglycoside O-phosphotransferase APH(3')-IIIa | - |
P3L36_RS03765 (P3L36_03765) | 678508..678591 | + | 84 | Protein_658 | MLS leader peptide | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Integrative and Conjugative Element | tet(O) / ant(6)-Ia / aph(3')-III / erm(B) | cylX / cylD / cylG / acpC / cylZ / cylA / cylB / cylE / cylF / cylI / cylJ / cylK | 611846..727472 | 115626 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 290 a.a. Molecular weight: 32902.55 Da Isoelectric Point: 4.9770
>T275327 WP_071661597.1 NZ_CP120654:672837-673706 [Streptococcus agalactiae]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEHKPEKYTE
KVNHIFEVLGISLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEHKPEKYTE
KVNHIFEVLGISLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI
Download Length: 870 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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