Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1266179..1267096 Replicon chromosome
Accession NZ_CP120641
Organism Bacillus velezensis strain YL2021

Toxin (Protein)


Gene name spoIISA Uniprot ID I2HQ15
Locus tag P6S76_RS06430 Protein ID WP_007407256.1
Coordinates 1266350..1267096 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag P6S76_RS06425 Protein ID WP_003154807.1
Coordinates 1266179..1266349 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6S76_RS06390 1261413..1263035 + 1623 WP_007407261.1 pyocin knob domain-containing protein -
P6S76_RS06395 1263048..1263419 + 372 WP_007407260.1 XkdW family protein -
P6S76_RS06400 1263424..1263621 + 198 WP_007407259.1 XkdX family protein -
P6S76_RS06405 1263678..1264439 + 762 WP_007407258.1 hypothetical protein -
P6S76_RS06410 1264491..1264754 + 264 WP_003154815.1 hemolysin XhlA family protein -
P6S76_RS06415 1264768..1265031 + 264 WP_003154813.1 phage holin -
P6S76_RS06420 1265045..1265923 + 879 WP_007407257.1 N-acetylmuramoyl-L-alanine amidase -
P6S76_RS06425 1266179..1266349 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
P6S76_RS06430 1266350..1267096 - 747 WP_007407256.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
P6S76_RS06435 1267201..1268199 - 999 WP_007407255.1 inorganic phosphate transporter -
P6S76_RS06440 1268212..1268829 - 618 WP_003154804.1 DUF47 domain-containing protein -
P6S76_RS06445 1269115..1270431 - 1317 WP_007407254.1 amino acid permease -
P6S76_RS06450 1270754..1271704 + 951 WP_007407253.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1232446..1275361 42915


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29077.57 Da        Isoelectric Point: 4.7755

>T275325 WP_007407256.1 NZ_CP120641:c1267096-1266350 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT275325 WP_003154807.1 NZ_CP120641:c1266349-1266179 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I2HQ15

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References