Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4601499..4602117 Replicon chromosome
Accession NZ_CP120633
Organism Escherichia coli strain USVAST219

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag P6O79_RS22480 Protein ID WP_001291435.1
Coordinates 4601499..4601717 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag P6O79_RS22485 Protein ID WP_000344800.1
Coordinates 4601743..4602117 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6O79_RS22445 (4596786) 4596786..4597358 + 573 WP_000779831.1 YbaY family lipoprotein -
P6O79_RS22450 (4597389) 4597389..4597700 - 312 WP_000409908.1 MGMT family protein -
P6O79_RS22460 (4598079) 4598079..4598432 + 354 WP_000878135.1 DUF1428 family protein -
P6O79_RS22465 (4598474) 4598474..4600024 - 1551 WP_001385227.1 cyclic-guanylate-specific phosphodiesterase PdeB -
P6O79_RS22470 (4600188) 4600188..4600658 - 471 WP_000136192.1 YlaC family protein -
P6O79_RS22475 (4600774) 4600774..4601325 - 552 WP_000102539.1 maltose O-acetyltransferase -
P6O79_RS22480 (4601499) 4601499..4601717 - 219 WP_001291435.1 HHA domain-containing protein Toxin
P6O79_RS22485 (4601743) 4601743..4602117 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
P6O79_RS22490 (4602663) 4602663..4605812 - 3150 WP_001132478.1 efflux RND transporter permease AcrB -
P6O79_RS22495 (4605835) 4605835..4607028 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T275309 WP_001291435.1 NZ_CP120633:c4601717-4601499 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT275309 WP_000344800.1 NZ_CP120633:c4602117-4601743 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References