Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 3796122..3796619 Replicon chromosome
Accession NZ_CP120633
Organism Escherichia coli strain USVAST219

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag P6O79_RS18680 Protein ID WP_001173343.1
Coordinates 3796446..3796619 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag P6O79_RS18675 Protein ID WP_001312331.1
Coordinates 3796122..3796418 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6O79_RS18665 (3791479) 3791479..3795408 + 3930 WP_001080129.1 autotransporter outer membrane beta-barrel domain-containing protein -
P6O79_RS18670 (3795622) 3795622..3795894 + 273 WP_000405647.1 GNAT family N-acetyltransferase -
P6O79_RS18675 (3796122) 3796122..3796418 + 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
P6O79_RS18680 (3796446) 3796446..3796619 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
P6O79_RS18685 (3796738) 3796738..3798255 - 1518 WP_000003806.1 lysine--tRNA ligase -
P6O79_RS18690 (3798492) 3798492..3799949 - 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3780535..3805473 24938


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T275304 WP_001173343.1 NZ_CP120633:3796446-3796619 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT275304 WP_001312331.1 NZ_CP120633:3796122-3796418 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References