Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2917063..2917863 Replicon chromosome
Accession NZ_CP120633
Organism Escherichia coli strain USVAST219

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag P6O79_RS14655 Protein ID WP_000342452.1
Coordinates 2917063..2917590 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag P6O79_RS14660 Protein ID WP_001277107.1
Coordinates 2917597..2917863 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6O79_RS14630 (2912139) 2912139..2912906 - 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
P6O79_RS14635 (2912903) 2912903..2914180 - 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
P6O79_RS14640 (2914177) 2914177..2915103 - 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
P6O79_RS14645 (2915151) 2915151..2916260 - 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
P6O79_RS14650 (2916683) 2916683..2917066 + 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
P6O79_RS14655 (2917063) 2917063..2917590 - 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
P6O79_RS14660 (2917597) 2917597..2917863 - 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
P6O79_RS14665 (2918012) 2918012..2919115 - 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
P6O79_RS14670 (2919386) 2919386..2920240 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
P6O79_RS14675 (2920485) 2920485..2921543 - 1059 WP_001042003.1 permease-like cell division protein FtsX -
P6O79_RS14680 (2921536) 2921536..2922204 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T275301 WP_000342452.1 NZ_CP120633:c2917590-2917063 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT275301 WP_001277107.1 NZ_CP120633:c2917863-2917597 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References