Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 4005174..4006828 Replicon chromosome
Accession NZ_CP120626
Organism Pseudomonas sp. NyZ480

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag P3R38_RS18350 Protein ID WP_023381733.1
Coordinates 4005174..4006010 (+) Length 279 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag P3R38_RS18355 Protein ID WP_027907431.1
Coordinates 4006016..4006828 (+) Length 271 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P3R38_RS18325 (P3R38_18325) 4001156..4002001 + 846 WP_023381728.1 ABC transporter ATP-binding protein -
P3R38_RS18330 (P3R38_18330) 4002033..4003034 + 1002 WP_023381729.1 ABC transporter substrate-binding protein -
P3R38_RS18335 (P3R38_18335) 4003063..4003839 + 777 WP_023381730.1 ABC transporter permease -
P3R38_RS18340 (P3R38_18340) 4003839..4004603 + 765 WP_023381731.1 SDR family oxidoreductase -
P3R38_RS18345 (P3R38_18345) 4004618..4005157 + 540 WP_023381732.1 cupin domain-containing protein -
P3R38_RS18350 (P3R38_18350) 4005174..4006010 + 837 WP_023381733.1 alpha/beta hydrolase Toxin
P3R38_RS18355 (P3R38_18355) 4006016..4006828 + 813 WP_027907431.1 IclR family transcriptional regulator Antitoxin
P3R38_RS18360 (P3R38_18360) 4006830..4007627 + 798 WP_023381735.1 SDR family oxidoreductase -
P3R38_RS18365 (P3R38_18365) 4007620..4009302 + 1683 WP_023381736.1 thiamine pyrophosphate-binding protein -
P3R38_RS18370 (P3R38_18370) 4009313..4010116 + 804 WP_023381737.1 aspartate dehydrogenase -
P3R38_RS18375 (P3R38_18375) 4010127..4011617 + 1491 WP_277686484.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(34-261)

Antitoxin

Transcription regulator IclR, N-terminal

(16-65)


Sequences

Toxin        


Download         Length: 279 a.a.        Molecular weight: 29113.38 Da        Isoelectric Point: 6.8859

>T275284 WP_023381733.1 NZ_CP120626:4005174-4006010 [Pseudomonas sp. NyZ480]
MPTPSLLDQRFAERLLRLDGGQLAVRQAGDGDAVVLLHGIGSGAASWLHVAMGLSERARVLAWDAPGYGQSSPLPMAAPS
ARDYAGRLLQALDTLGIERCVLVGHSLGALTASAFAQACPERVNRLVLISPARGYGAVPDQGRAVRAERLHNLGQLGIER
MARERSARLLSANASAEAQAWVHWNMARLKPHGYRQAIELLCGDDLLRYAPLAVACQVHCGSADGITLPEDCAALAAALA
APFDLIAGAGHACAIEQPDTVTGLLARALDASLTGSVL

Download         Length: 837 bp

Antitoxin


Download         Length: 271 a.a.        Molecular weight: 29767.26 Da        Isoelectric Point: 6.6423

>AT275284 WP_027907431.1 NZ_CP120626:4006016-4006828 [Pseudomonas sp. NyZ480]
MDPLKENQDKYIVPGLERGLLLLCEFSRQNRTLTAPELARRLSLPRSTIFRLLTTLETMGFVTRSGNEYRLGMSVLRLGF
EYLASLELTELGQPLLARLCDHLNYPSNLVVRDGRSIVYVAKVSPPSVFSSAVTVGTRLPAHATVLGRILLADLSLAELR
ELYPEEHLEQYSPCTPKTVLELFDLVQADRLRGYVSGEGFFESTISTVAAPVRDASGQVVAALGLTIPTVQIGHVNFDNL
LGQVRGSADELSRLLNYRPGSGHVTALMRD

Download         Length: 813 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References