Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2269843..2270479 Replicon chromosome
Accession NZ_CP120625
Organism Bacillus altitudinis strain DSM 103869

Toxin (Protein)


Gene name mazF Uniprot ID K2MHT4
Locus tag P5623_RS12625 Protein ID WP_003214169.1
Coordinates 2269843..2270193 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W8QJ31
Locus tag P5623_RS12630 Protein ID WP_003214273.1
Coordinates 2270198..2270479 (-) Length 94 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5623_RS12585 (P5623_12585) 2264875..2265474 - 600 WP_008346897.1 PP2C family serine/threonine-protein phosphatase -
P5623_RS12590 (P5623_12590) 2265474..2266262 - 789 WP_012009000.1 RNA polymerase sigma factor SigB -
P5623_RS12595 (P5623_12595) 2266228..2266716 - 489 WP_007496471.1 anti-sigma B factor RsbW -
P5623_RS12600 (P5623_12600) 2266713..2267042 - 330 WP_019744215.1 anti-sigma factor antagonist -
P5623_RS12605 (P5623_12605) 2267102..2268110 - 1009 Protein_2372 PP2C family protein-serine/threonine phosphatase -
P5623_RS12610 (P5623_12610) 2268121..2268522 - 402 WP_003214085.1 anti-sigma regulatory factor -
P5623_RS12615 (P5623_12615) 2268525..2268893 - 369 WP_003214235.1 RsbT antagonist protein RsbS -
P5623_RS12620 (P5623_12620) 2268898..2269728 - 831 WP_007496484.1 RsbT co-antagonist protein RsbRA -
P5623_RS12625 (P5623_12625) 2269843..2270193 - 351 WP_003214169.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
P5623_RS12630 (P5623_12630) 2270198..2270479 - 282 WP_003214273.1 hypothetical protein Antitoxin
P5623_RS12635 (P5623_12635) 2270773..2271954 - 1182 WP_035704220.1 alanine racemase -
P5623_RS12640 (P5623_12640) 2272083..2273099 - 1017 WP_007496489.1 outer membrane lipoprotein-sorting protein -
P5623_RS12645 (P5623_12645) 2273260..2273625 - 366 WP_017358398.1 holo-ACP synthase -
P5623_RS12650 (P5623_12650) 2273720..2274325 + 606 WP_007496491.1 rhomboid family intramembrane serine protease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-113)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 12976.99 Da        Isoelectric Point: 5.1663

>T275283 WP_003214169.1 NZ_CP120625:c2270193-2269843 [Bacillus altitudinis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEINAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp


Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10864.25 Da        Isoelectric Point: 5.2726

>AT275283 WP_003214273.1 NZ_CP120625:c2270479-2270198 [Bacillus altitudinis]
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB K2MHT4


Antitoxin

Source ID Structure
AlphaFold DB A0A081L854

References