Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 2269843..2270479 | Replicon | chromosome |
Accession | NZ_CP120625 | ||
Organism | Bacillus altitudinis strain DSM 103869 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | K2MHT4 |
Locus tag | P5623_RS12625 | Protein ID | WP_003214169.1 |
Coordinates | 2269843..2270193 (-) | Length | 117 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | W8QJ31 |
Locus tag | P5623_RS12630 | Protein ID | WP_003214273.1 |
Coordinates | 2270198..2270479 (-) | Length | 94 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
P5623_RS12585 (P5623_12585) | 2264875..2265474 | - | 600 | WP_008346897.1 | PP2C family serine/threonine-protein phosphatase | - |
P5623_RS12590 (P5623_12590) | 2265474..2266262 | - | 789 | WP_012009000.1 | RNA polymerase sigma factor SigB | - |
P5623_RS12595 (P5623_12595) | 2266228..2266716 | - | 489 | WP_007496471.1 | anti-sigma B factor RsbW | - |
P5623_RS12600 (P5623_12600) | 2266713..2267042 | - | 330 | WP_019744215.1 | anti-sigma factor antagonist | - |
P5623_RS12605 (P5623_12605) | 2267102..2268110 | - | 1009 | Protein_2372 | PP2C family protein-serine/threonine phosphatase | - |
P5623_RS12610 (P5623_12610) | 2268121..2268522 | - | 402 | WP_003214085.1 | anti-sigma regulatory factor | - |
P5623_RS12615 (P5623_12615) | 2268525..2268893 | - | 369 | WP_003214235.1 | RsbT antagonist protein RsbS | - |
P5623_RS12620 (P5623_12620) | 2268898..2269728 | - | 831 | WP_007496484.1 | RsbT co-antagonist protein RsbRA | - |
P5623_RS12625 (P5623_12625) | 2269843..2270193 | - | 351 | WP_003214169.1 | type II toxin-antitoxin system endoribonuclease NdoA | Toxin |
P5623_RS12630 (P5623_12630) | 2270198..2270479 | - | 282 | WP_003214273.1 | hypothetical protein | Antitoxin |
P5623_RS12635 (P5623_12635) | 2270773..2271954 | - | 1182 | WP_035704220.1 | alanine racemase | - |
P5623_RS12640 (P5623_12640) | 2272083..2273099 | - | 1017 | WP_007496489.1 | outer membrane lipoprotein-sorting protein | - |
P5623_RS12645 (P5623_12645) | 2273260..2273625 | - | 366 | WP_017358398.1 | holo-ACP synthase | - |
P5623_RS12650 (P5623_12650) | 2273720..2274325 | + | 606 | WP_007496491.1 | rhomboid family intramembrane serine protease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12976.99 Da Isoelectric Point: 5.1663
>T275283 WP_003214169.1 NZ_CP120625:c2270193-2269843 [Bacillus altitudinis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEINAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEINAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF
Download Length: 351 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | K2MHT4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A081L854 |