275276

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1297759..1298675 Replicon chromosome
Accession NZ_CP120622
Organism Bacillus subtilis strain DSM 1090

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag P5647_RS06810 Protein ID WP_003244695.1
Coordinates 1297929..1298675 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag P5647_RS06805 Protein ID WP_003232646.1
Coordinates 1297759..1297929 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5647_RS06770 (1294622) 1294622..1294951 + 330 WP_003232660.1 XkdW family protein -
P5647_RS06775 (1294948) 1294948..1295112 + 165 WP_003232658.1 XkdX family protein -
P5647_RS06780 (1295156) 1295156..1295995 + 840 WP_003245597.1 phage-like element PBSX protein XepA -
P5647_RS06785 (1296048) 1296048..1296317 + 270 WP_003232655.1 hemolysin XhlA family protein -
P5647_RS06790 (1296330) 1296330..1296593 + 264 WP_003232653.1 phage holin -
P5647_RS06795 (1296606) 1296606..1297499 + 894 WP_003245230.1 N-acetylmuramoyl-L-alanine amidase -
P5647_RS06800 (1297536) 1297536..1297673 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
P5647_RS06805 (1297759) 1297759..1297929 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
P5647_RS06810 (1297929) 1297929..1298675 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
P5647_RS06815 (1298785) 1298785..1299786 - 1002 WP_003232642.1 inorganic phosphate transporter -
P5647_RS06820 (1299799) 1299799..1300416 - 618 WP_003218470.1 DUF47 domain-containing protein -
P5647_RS06825 (1300692) 1300692..1302008 - 1317 WP_003244819.1 serine/threonine exchanger -
P5647_RS06830 (1302397) 1302397..1303347 + 951 WP_003245086.1 ring-cleaving dioxygenase -
P5647_RS06835 (1303448) 1303448..1303594 + 147 WP_003244977.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T275276 WP_003244695.1 NZ_CP120622:c1298675-1297929 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT275276 WP_003232646.1 NZ_CP120622:c1297929-1297759 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References