275271

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 247161..247797 Replicon chromosome
Accession NZ_CP120618
Organism Priestia megaterium strain DSM 1804

Toxin (Protein)


Gene name mazF Uniprot ID D5DWT4
Locus tag P5632_RS01805 Protein ID WP_013055004.1
Coordinates 247161..247511 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID D5DWT3
Locus tag P5632_RS01810 Protein ID WP_013055003.1
Coordinates 247516..247797 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5632_RS01770 (P5632_01770) 242745..243539 - 795 WP_013055011.1 RNA polymerase sigma factor SigB -
P5632_RS01775 (P5632_01775) 243505..243990 - 486 WP_013055010.1 anti-sigma B factor RsbW -
P5632_RS01780 (P5632_01780) 243987..244319 - 333 WP_013055009.1 anti-sigma factor antagonist -
P5632_RS01785 (P5632_01785) 244379..245389 - 1011 WP_013055008.1 PP2C family protein-serine/threonine phosphatase -
P5632_RS01790 (P5632_01790) 245403..245804 - 402 WP_013055007.1 anti-sigma regulatory factor -
P5632_RS01795 (P5632_01795) 245808..246164 - 357 WP_013055006.1 STAS domain-containing protein -
P5632_RS01800 (P5632_01800) 246167..247003 - 837 WP_013055005.1 RsbT co-antagonist protein RsbRA -
P5632_RS01805 (P5632_01805) 247161..247511 - 351 WP_013055004.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
P5632_RS01810 (P5632_01810) 247516..247797 - 282 WP_013055003.1 hypothetical protein Antitoxin
P5632_RS01815 (P5632_01815) 247998..249188 - 1191 WP_013055002.1 alanine racemase -
P5632_RS01820 (P5632_01820) 249302..250360 - 1059 WP_013055001.1 outer membrane lipoprotein carrier protein LolA -
P5632_RS01825 (P5632_01825) 250419..250784 - 366 WP_013055000.1 holo-ACP synthase -
P5632_RS01830 (P5632_01830) 250849..251451 + 603 WP_013054999.1 rhomboid family intramembrane serine protease -
P5632_RS01835 (P5632_01835) 251460..252431 - 972 WP_013054998.1 UV DNA damage repair endonuclease UvsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12991.96 Da        Isoelectric Point: 4.8781

>T275271 WP_013055004.1 NZ_CP120618:c247511-247161 [Priestia megaterium]
MVVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDRVDEALQISVGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10691.22 Da        Isoelectric Point: 8.5339

>AT275271 WP_013055003.1 NZ_CP120618:c247797-247516 [Priestia megaterium]
VSEASATTEILVRLPKNLVSELDLMVKQENGNRSDFIHQATKLYLRERKKRHIRESMRRGYMEMAKINLNIASEAFLAEY
EADHTVDRLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0B6AMB9

References