275270

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 3806944..3807860 Replicon chromosome
Accession NZ_CP120613
Organism Bacillus subtilis strain DSM 23521

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag P5649_RS19865 Protein ID WP_003244695.1
Coordinates 3806944..3807690 (+) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag P5649_RS19870 Protein ID WP_003232646.1
Coordinates 3807690..3807860 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5649_RS19840 (3802025) 3802025..3802171 - 147 WP_003244977.1 hypothetical protein -
P5649_RS19845 (3802272) 3802272..3803222 - 951 WP_003245086.1 ring-cleaving dioxygenase -
P5649_RS19850 (3803611) 3803611..3804927 + 1317 WP_003244819.1 serine/threonine exchanger -
P5649_RS19855 (3805203) 3805203..3805820 + 618 WP_003218470.1 DUF47 domain-containing protein -
P5649_RS19860 (3805833) 3805833..3806834 + 1002 WP_003232642.1 inorganic phosphate transporter -
P5649_RS19865 (3806944) 3806944..3807690 + 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
P5649_RS19870 (3807690) 3807690..3807860 + 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
P5649_RS19875 (3807946) 3807946..3808083 + 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
P5649_RS19880 (3808120) 3808120..3809013 - 894 WP_003245230.1 N-acetylmuramoyl-L-alanine amidase -
P5649_RS19885 (3809026) 3809026..3809289 - 264 WP_003232653.1 phage holin -
P5649_RS19890 (3809302) 3809302..3809571 - 270 WP_003232655.1 hemolysin XhlA family protein -
P5649_RS19895 (3809624) 3809624..3810463 - 840 WP_003245597.1 phage-like element PBSX protein XepA -
P5649_RS19900 (3810507) 3810507..3810671 - 165 WP_003232658.1 XkdX family protein -
P5649_RS19905 (3810668) 3810668..3810997 - 330 WP_003232660.1 XkdW family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T275270 WP_003244695.1 NZ_CP120613:3806944-3807690 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT275270 WP_003232646.1 NZ_CP120613:3807690-3807860 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
AlphaFold DB G4EXD8

References