275249

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1467006..1467925 Replicon chromosome
Accession NZ_CP120610
Organism Bacillus paralicheniformis strain DSM 28591

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A6I7TYV7
Locus tag P5653_RS07635 Protein ID WP_023856735.1
Coordinates 1467179..1467925 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID A0A6I7TM13
Locus tag P5653_RS07630 Protein ID WP_023856734.1
Coordinates 1467006..1467179 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5653_RS07605 (P5653_07605) 1462431..1463528 + 1098 WP_023856730.1 mannonate dehydratase -
P5653_RS07610 (P5653_07610) 1463504..1464352 + 849 WP_023856787.1 SDR family oxidoreductase -
P5653_RS07615 (P5653_07615) 1464378..1465391 + 1014 WP_023856731.1 zinc-binding alcohol dehydrogenase family protein -
P5653_RS07620 (P5653_07620) 1465443..1466714 + 1272 WP_023856732.1 MFS transporter -
P5653_RS07625 (P5653_07625) 1466781..1466912 - 132 WP_023856733.1 hypothetical protein -
P5653_RS07630 (P5653_07630) 1467006..1467179 - 174 WP_023856734.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
P5653_RS07635 (P5653_07635) 1467179..1467925 - 747 WP_023856735.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
P5653_RS07640 (P5653_07640) 1468035..1469033 - 999 WP_023856736.1 inorganic phosphate transporter -
P5653_RS07645 (P5653_07645) 1469046..1469663 - 618 WP_023856737.1 DUF47 domain-containing protein -
P5653_RS07650 (P5653_07650) 1469996..1471753 + 1758 WP_023856738.1 gamma-glutamyltransferase -
P5653_RS07655 (P5653_07655) 1471888..1472532 + 645 WP_023856740.1 YesL family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-57)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29421.87 Da        Isoelectric Point: 4.6015

>T275249 WP_023856735.1 NZ_CP120610:c1467925-1467179 [Bacillus paralicheniformis]
MLLFYQFLVWLIVLALALYVAAVWRFEKKLTEKTVAIRKTWYLLYVIGAVIYWTHDPQSIFTNPLHYLIVAVFFTLTDAF
IFLNAYFKKLGSSELATDTRMLLEENNDLLHTYQNRLKTFQYLLKNEPIHIYYGNIEAYAEGIEKLIKRFAEKMNISAAL
CEYNSEESKDHLLEHMENRFDVQEKLERKDVYYEENGKMVLIPFSIHDFDYVMKLTSEDLVTEFDYLLFTSLTSIYDLLL
PNEEDGDD

Download         Length: 747 bp

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6897.99 Da        Isoelectric Point: 10.8356

>AT275249 WP_023856734.1 NZ_CP120610:c1467179-1467006 [Bacillus paralicheniformis]
MEPAFQQDHESAKKRLAFKMFKKQSKTNIAKYEVSPHTERIFRQNERLIGEYKRKKA

Download         Length: 174 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7TYV7

Antitoxin

Source ID Structure
AlphaFold DB A0A6I7TM13

References