275245

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4109763..4110399 Replicon chromosome
Accession NZ_CP120601
Organism Bacillus paralicheniformis strain PRO109

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag P5637_RS20995 Protein ID WP_003179128.1
Coordinates 4110049..4110399 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M5PDU2
Locus tag P5637_RS20990 Protein ID WP_006638778.1
Coordinates 4109763..4110044 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5637_RS20970 (P5637_20970) 4104875..4106358 + 1484 Protein_4115 PH domain-containing protein -
P5637_RS20975 (P5637_20975) 4106355..4106954 - 600 WP_023857867.1 rhomboid family intramembrane serine protease -
P5637_RS20980 (P5637_20980) 4107298..4108257 + 960 WP_164468292.1 outer membrane lipoprotein carrier protein LolA -
P5637_RS20985 (P5637_20985) 4108482..4109651 + 1170 WP_023857864.1 alanine racemase -
P5637_RS20990 (P5637_20990) 4109763..4110044 + 282 WP_006638778.1 hypothetical protein Antitoxin
P5637_RS20995 (P5637_20995) 4110049..4110399 + 351 WP_003179128.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
P5637_RS21000 (P5637_21000) 4110517..4111344 + 828 WP_145685330.1 RsbT co-antagonist protein RsbRA -
P5637_RS21005 (P5637_21005) 4111348..4111713 + 366 WP_020450259.1 STAS domain-containing protein -
P5637_RS21010 (P5637_21010) 4111716..4112117 + 402 WP_020450260.1 anti-sigma regulatory factor -
P5637_RS21015 (P5637_21015) 4112128..4113135 + 1008 WP_020450261.1 PP2C family protein-serine/threonine phosphatase -
P5637_RS21020 (P5637_21020) 4113194..4113520 + 327 WP_020450262.1 anti-sigma factor antagonist -
P5637_RS21025 (P5637_21025) 4113520..4114002 + 483 WP_020450263.1 anti-sigma B factor RsbW -
P5637_RS21030 (P5637_21030) 4113968..4114759 + 792 WP_023857858.1 RNA polymerase sigma factor SigB -
P5637_RS21035 (P5637_21035) 4114756..4115355 + 600 WP_145685333.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T275245 WP_003179128.1 NZ_CP120601:4110049-4110399 [Bacillus paralicheniformis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.03 Da        Isoelectric Point: 4.6920

>AT275245 WP_006638778.1 NZ_CP120601:4109763-4110044 [Bacillus paralicheniformis]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7FHI4

Antitoxin

Source ID Structure
AlphaFold DB M5PDU2

References