275244

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1419052..1419968 Replicon chromosome
Accession NZ_CP120600
Organism Bacillus subtilis strain PRO112

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag P5661_RS07635 Protein ID WP_003244695.1
Coordinates 1419222..1419968 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag P5661_RS07630 Protein ID WP_003232646.1
Coordinates 1419052..1419222 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5661_RS07595 (P5661_07595) 1415914..1416240 + 327 WP_277709537.1 XkdW family protein -
P5661_RS07600 (P5661_07600) 1416237..1416401 + 165 WP_014479563.1 XkdX family protein -
P5661_RS07605 (P5661_07605) 1416448..1417287 + 840 WP_124073160.1 phage-like element PBSX protein XepA -
P5661_RS07610 (P5661_07610) 1417340..1417609 + 270 WP_014479565.1 hemolysin XhlA family protein -
P5661_RS07615 (P5661_07615) 1417622..1417885 + 264 WP_014479566.1 phage holin -
P5661_RS07620 (P5661_07620) 1417898..1418791 + 894 WP_021479459.1 N-acetylmuramoyl-L-alanine amidase -
P5661_RS07625 (P5661_07625) 1418829..1418966 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
P5661_RS07630 (P5661_07630) 1419052..1419222 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
P5661_RS07635 (P5661_07635) 1419222..1419968 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
P5661_RS07640 (P5661_07640) 1420078..1421079 - 1002 WP_003232642.1 inorganic phosphate transporter -
P5661_RS07645 (P5661_07645) 1421092..1421709 - 618 WP_277709538.1 DUF47 domain-containing protein -
P5661_RS07650 (P5661_07650) 1421985..1423301 - 1317 WP_042974295.1 serine/threonine exchanger -
P5661_RS07655 (P5661_07655) 1423690..1424640 + 951 WP_015252261.1 ring-cleaving dioxygenase -
P5661_RS07660 (P5661_07660) 1424749..1424850 + 102 Protein_1444 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T275244 WP_003244695.1 NZ_CP120600:c1419968-1419222 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT275244 WP_003232646.1 NZ_CP120600:c1419222-1419052 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References