Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 61506..62142 Replicon chromosome
Accession NZ_CP120599
Organism Bacillus safensis strain PRO114

Toxin (Protein)


Gene name mazF Uniprot ID A0A0P7G713
Locus tag P5638_RS00390 Protein ID WP_024425388.1
Coordinates 61506..61856 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W8QJ31
Locus tag P5638_RS00395 Protein ID WP_003214273.1
Coordinates 61861..62142 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5638_RS00350 (P5638_00350) 56537..57136 - 600 WP_277722414.1 PP2C family serine/threonine-protein phosphatase -
P5638_RS00355 (P5638_00355) 57136..57924 - 789 WP_277722415.1 RNA polymerase sigma factor SigB -
P5638_RS00360 (P5638_00360) 57890..58378 - 489 WP_024425393.1 anti-sigma B factor RsbW -
P5638_RS00365 (P5638_00365) 58375..58704 - 330 WP_024425392.1 anti-sigma factor antagonist -
P5638_RS00370 (P5638_00370) 58764..59771 - 1008 WP_024425391.1 PP2C family protein-serine/threonine phosphatase -
P5638_RS00375 (P5638_00375) 59782..60183 - 402 WP_024425390.1 anti-sigma regulatory factor -
P5638_RS00380 (P5638_00380) 60186..60554 - 369 WP_003214235.1 RsbT antagonist protein RsbS -
P5638_RS00385 (P5638_00385) 60559..61389 - 831 WP_034622604.1 RsbT co-antagonist protein RsbRA -
P5638_RS00390 (P5638_00390) 61506..61856 - 351 WP_024425388.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
P5638_RS00395 (P5638_00395) 61861..62142 - 282 WP_003214273.1 hypothetical protein Antitoxin
P5638_RS00400 (P5638_00400) 62436..63617 - 1182 WP_263905473.1 alanine racemase -
P5638_RS00405 (P5638_00405) 63759..64775 - 1017 WP_087975235.1 outer membrane lipoprotein-sorting protein -
P5638_RS00410 (P5638_00410) 64936..65302 - 367 Protein_70 holo-ACP synthase -
P5638_RS00415 (P5638_00415) 65397..66002 + 606 WP_024425384.1 rhomboid family intramembrane serine protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8891

>T275242 WP_024425388.1 NZ_CP120599:c61856-61506 [Bacillus safensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10864.25 Da        Isoelectric Point: 5.2726

>AT275242 WP_003214273.1 NZ_CP120599:c62142-61861 [Bacillus safensis]
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P7G713

Antitoxin

Source ID Structure
AlphaFold DB A0A081L854

References