275241

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 3431395..3432311 Replicon chromosome
Accession NZ_CP120598
Organism Bacillus subtilis strain PRO115

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag P5622_RS17840 Protein ID WP_003244695.1
Coordinates 3431395..3432141 (+) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag P5622_RS17845 Protein ID WP_003232646.1
Coordinates 3432141..3432311 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5622_RS17815 (3426476) 3426476..3426622 - 147 WP_003244977.1 hypothetical protein -
P5622_RS17820 (3426723) 3426723..3427673 - 951 WP_003245086.1 ring-cleaving dioxygenase -
P5622_RS17825 (3428062) 3428062..3429378 + 1317 WP_003244819.1 serine/threonine exchanger -
P5622_RS17830 (3429654) 3429654..3430271 + 618 WP_003218470.1 DUF47 domain-containing protein -
P5622_RS17835 (3430284) 3430284..3431285 + 1002 WP_003232642.1 inorganic phosphate transporter -
P5622_RS17840 (3431395) 3431395..3432141 + 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
P5622_RS17845 (3432141) 3432141..3432311 + 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
P5622_RS17850 (3432397) 3432397..3432534 + 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
P5622_RS17855 (3432571) 3432571..3433464 - 894 WP_003245230.1 N-acetylmuramoyl-L-alanine amidase -
P5622_RS17860 (3433477) 3433477..3433740 - 264 WP_003232653.1 phage holin -
P5622_RS17865 (3433753) 3433753..3434022 - 270 WP_003232655.1 hemolysin XhlA family protein -
P5622_RS17870 (3434075) 3434075..3434914 - 840 WP_003245597.1 phage-like element PBSX protein XepA -
P5622_RS17875 (3434958) 3434958..3435122 - 165 WP_003232658.1 XkdX family protein -
P5622_RS17880 (3435119) 3435119..3435448 - 330 WP_003232660.1 XkdW family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T275241 WP_003244695.1 NZ_CP120598:3431395-3432141 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT275241 WP_003232646.1 NZ_CP120598:3432141-3432311 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References