Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yxiD-yxxD/- |
| Location | 2432615..2433750 | Replicon | chromosome |
| Accession | NZ_CP120590 | ||
| Organism | Priestia flexa strain PRO116 | ||
Toxin (Protein)
| Gene name | yxiD | Uniprot ID | - |
| Locus tag | P5663_RS12880 | Protein ID | WP_277716493.1 |
| Coordinates | 2432615..2433307 (+) | Length | 231 a.a. |
Antitoxin (Protein)
| Gene name | yxxD | Uniprot ID | - |
| Locus tag | P5663_RS12885 | Protein ID | WP_277716494.1 |
| Coordinates | 2433313..2433750 (+) | Length | 146 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| P5663_RS12855 (P5663_12865) | 2427662..2427922 | + | 261 | WP_025907985.1 | DUF5344 family protein | - |
| P5663_RS12860 (P5663_12870) | 2427941..2430115 | + | 2175 | WP_277716491.1 | deaminase domain-containing protein | - |
| P5663_RS12865 (P5663_12875) | 2430143..2430499 | + | 357 | WP_045291793.1 | Imm3 family immunity protein | - |
| P5663_RS12870 (P5663_12880) | 2430955..2431566 | + | 612 | WP_277716492.1 | polymorphic toxin type 15 domain-containing protein | - |
| P5663_RS12875 (P5663_12885) | 2431581..2432123 | + | 543 | WP_061786728.1 | DUF1851 domain-containing protein | - |
| P5663_RS12880 (P5663_12890) | 2432615..2433307 | + | 693 | WP_277716493.1 | HNH endonuclease | Toxin |
| P5663_RS12885 (P5663_12895) | 2433313..2433750 | + | 438 | WP_277716494.1 | SMI1/KNR4 family protein | Antitoxin |
| P5663_RS12890 (P5663_12900) | 2434519..2434950 | + | 432 | WP_277716495.1 | DNA/RNA non-specific endonuclease | - |
| P5663_RS12895 (P5663_12905) | 2434962..2435438 | + | 477 | WP_078989704.1 | DUF600 domain-containing protein | - |
| P5663_RS12900 (P5663_12910) | 2435880..2436773 | + | 894 | WP_277716496.1 | HNH endonuclease | - |
| P5663_RS12905 (P5663_12915) | 2436779..2437264 | + | 486 | WP_078989700.1 | hypothetical protein | - |
| P5663_RS12910 (P5663_12920) | 2437687..2438085 | + | 399 | WP_277716497.1 | hypothetical protein | - |
| P5663_RS12915 (P5663_12925) | 2438090..2438662 | + | 573 | WP_277716498.1 | HNH endonuclease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 231 a.a. Molecular weight: 26686.40 Da Isoelectric Point: 10.1902
>T275233 WP_277716493.1 NZ_CP120590:2432615-2433307 [Priestia flexa]
MPKLAPAGPALAQQTVRETLQNVKQQAMQMITPIYNPKVKRYQDPETGRFVANPNVERVEKPVGVEKKGKEVKSVRNVES
VQDVSKGTVKIDYDLAKEYIRDVESKTGLKLHKSQIEKLKDTLRENKYEKMTPLETLKHRNTFNSVKNKLIKEWEENTRQ
TWPRYTEEIYDKKGRLARDIGQPYDAHHIIENNFGGPHEWWNIHPAKFPDEHQAGIHGKGAPSNKLFPRR
MPKLAPAGPALAQQTVRETLQNVKQQAMQMITPIYNPKVKRYQDPETGRFVANPNVERVEKPVGVEKKGKEVKSVRNVES
VQDVSKGTVKIDYDLAKEYIRDVESKTGLKLHKSQIEKLKDTLRENKYEKMTPLETLKHRNTFNSVKNKLIKEWEENTRQ
TWPRYTEEIYDKKGRLARDIGQPYDAHHIIENNFGGPHEWWNIHPAKFPDEHQAGIHGKGAPSNKLFPRR
Download Length: 693 bp
Antitoxin
Download Length: 146 a.a. Molecular weight: 16983.00 Da Isoelectric Point: 3.8989
>AT275233 WP_277716494.1 NZ_CP120590:2433313-2433750 [Priestia flexa]
MATFDFVKNEKHKFIRLQENELLDAEERLGFELPNELRDFYLEVGYGFIKGRDGNTINRIMDPDTIADITLREGIYEFDP
DLEGIYEEDDKLVFYEVNEGVYLTLDLNTPQQTPVYFLETQIAGSLGEFIRKVVEDPEYFMDMAN
MATFDFVKNEKHKFIRLQENELLDAEERLGFELPNELRDFYLEVGYGFIKGRDGNTINRIMDPDTIADITLREGIYEFDP
DLEGIYEEDDKLVFYEVNEGVYLTLDLNTPQQTPVYFLETQIAGSLGEFIRKVVEDPEYFMDMAN
Download Length: 438 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|