Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 72307..72932 Replicon plasmid p582_124850
Accession NZ_CP120569
Organism Escherichia coli strain 582

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag P5711_RS24165 Protein ID WP_000911313.1
Coordinates 72534..72932 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag P5711_RS24160 Protein ID WP_000450520.1
Coordinates 72307..72534 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5711_RS24160 (72307) 72307..72534 + 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin
P5711_RS24165 (72534) 72534..72932 + 399 WP_000911313.1 type II toxin-antitoxin system VapC family toxin Toxin
P5711_RS24170 (72941) 72941..75175 - 2235 WP_089078723.1 type IV conjugative transfer system coupling protein TraD -
P5711_RS24175 (75428) 75428..76159 - 732 WP_023565183.1 conjugal transfer complement resistance protein TraT -
P5711_RS24180 (76191) 76191..76688 - 498 WP_000605857.1 entry exclusion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - iroB / iroC / iroD / iroE / iroN / vat 1..124850 124850


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14901.15 Da        Isoelectric Point: 7.8605

>T275226 WP_000911313.1 NZ_CP120569:72534-72932 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT275226 WP_000450520.1 NZ_CP120569:72307-72534 [Escherichia coli]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References