Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4207205..4207781 Replicon chromosome
Accession NZ_CP120568
Organism Escherichia coli strain 582

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag P5711_RS20685 Protein ID WP_001297643.1
Coordinates 4207494..4207781 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag P5711_RS20680 Protein ID WP_000063156.1
Coordinates 4207205..4207507 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5711_RS20665 (4203801) 4203801..4205951 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
P5711_RS20670 (4206001) 4206001..4206204 + 204 WP_000467859.1 YbdD/YjiX family protein -
P5711_RS20675 (4206215) 4206215..4207171 + 957 WP_001297640.1 GTPase -
P5711_RS20680 (4207205) 4207205..4207507 - 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
P5711_RS20685 (4207494) 4207494..4207781 - 288 WP_001297643.1 BrnT family toxin Toxin
P5711_RS20690 (4207980) 4207980..4208677 - 698 Protein_4045 IS1 family transposase -
P5711_RS20695 (4208734) 4208734..4208829 + 96 Protein_4046 dienelactone hydrolase family protein -
P5711_RS20700 (4208975) 4208975..4210207 + 1233 WP_001339512.1 multidrug efflux MFS transporter MdtM -
P5711_RS20705 (4210248) 4210248..4211528 + 1281 WP_001037380.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T275220 WP_001297643.1 NZ_CP120568:c4207781-4207494 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT275220 WP_000063156.1 NZ_CP120568:c4207507-4207205 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References