Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3657084..3657702 Replicon chromosome
Accession NZ_CP120568
Organism Escherichia coli strain 582

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag P5711_RS18045 Protein ID WP_001291435.1
Coordinates 3657484..3657702 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag P5711_RS18040 Protein ID WP_000344800.1
Coordinates 3657084..3657458 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5711_RS18030 (3652173) 3652173..3653366 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P5711_RS18035 (3653389) 3653389..3656538 + 3150 WP_046952227.1 efflux RND transporter permease AcrB -
P5711_RS18040 (3657084) 3657084..3657458 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
P5711_RS18045 (3657484) 3657484..3657702 + 219 WP_001291435.1 HHA domain-containing protein Toxin
P5711_RS18050 (3657874) 3657874..3658425 + 552 WP_000102564.1 maltose O-acetyltransferase -
P5711_RS18055 (3658541) 3658541..3659011 + 471 WP_000136192.1 YlaC family protein -
P5711_RS18060 (3659175) 3659175..3660725 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
P5711_RS18065 (3660767) 3660767..3661120 - 354 WP_000878140.1 DUF1428 domain-containing protein -
P5711_RS18075 (3661499) 3661499..3661810 + 312 WP_000409911.1 MGMT family protein -
P5711_RS18080 (3661841) 3661841..3662413 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T275217 WP_001291435.1 NZ_CP120568:3657484-3657702 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT275217 WP_000344800.1 NZ_CP120568:3657084-3657458 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References