Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2542890..2543528 Replicon chromosome
Accession NZ_CP120568
Organism Escherichia coli strain 582

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag P5711_RS12410 Protein ID WP_000813794.1
Coordinates 2543352..2543528 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag P5711_RS12405 Protein ID WP_001270286.1
Coordinates 2542890..2543306 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5711_RS12385 (2538042) 2538042..2538983 - 942 WP_001251304.1 ABC transporter permease -
P5711_RS12390 (2538984) 2538984..2539997 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
P5711_RS12395 (2540015) 2540015..2541160 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
P5711_RS12400 (2541405) 2541405..2542811 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
P5711_RS12405 (2542890) 2542890..2543306 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
P5711_RS12410 (2543352) 2543352..2543528 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
P5711_RS12415 (2543750) 2543750..2543980 + 231 WP_000494244.1 YncJ family protein -
P5711_RS12420 (2544072) 2544072..2546033 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
P5711_RS12425 (2546106) 2546106..2546642 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
P5711_RS12430 (2546734) 2546734..2546895 + 162 Protein_2431 benzoate/H(+) symporter BenE family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T275216 WP_000813794.1 NZ_CP120568:c2543528-2543352 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT275216 WP_001270286.1 NZ_CP120568:c2543306-2542890 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References