Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2387055..2387581 Replicon chromosome
Accession NZ_CP120568
Organism Escherichia coli strain 582

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag P5711_RS11620 Protein ID WP_000323025.1
Coordinates 2387294..2387581 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag P5711_RS11615 Protein ID WP_000534858.1
Coordinates 2387055..2387294 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5711_RS11590 (2384440) 2384440..2384829 + 390 WP_016230970.1 helix-turn-helix domain-containing protein -
P5711_RS11595 (2384854) 2384854..2385480 + 627 Protein_2264 ISNCY family transposase -
P5711_RS11600 (2385604) 2385604..2385753 + 150 WP_011443592.1 protein YdfW -
P5711_RS11605 (2386190) 2386190..2386522 - 333 WP_001301033.1 FlxA-like family protein -
P5711_RS11610 (2386725) 2386725..2387030 - 306 WP_001326990.1 protein YdfV -
P5711_RS11615 (2387055) 2387055..2387294 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
P5711_RS11620 (2387294) 2387294..2387581 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
P5711_RS11625 (2387653) 2387653..2387808 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
P5711_RS11630 (2388025) 2388025..2388276 + 252 WP_000980994.1 protein Rem -
P5711_RS11635 (2388343) 2388343..2388621 + 279 WP_012304870.1 hypothetical protein -
P5711_RS11640 (2388623) 2388623..2389021 + 399 Protein_2273 hypothetical protein -
P5711_RS11645 (2389167) 2389167..2389753 + 587 Protein_2274 transposase -
P5711_RS11650 (2389792) 2389792..2391330 - 1539 WP_001554465.1 IS66-like element ISEc22 family transposase -
P5711_RS11655 (2391379) 2391379..2391726 - 348 WP_000612626.1 IS66 family insertion sequence element accessory protein TnpB -
P5711_RS11660 (2391723) 2391723..2392127 - 405 WP_000839179.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2359533..2426258 66725


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T275214 WP_000323025.1 NZ_CP120568:2387294-2387581 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT275214 WP_000534858.1 NZ_CP120568:2387055-2387294 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References